ComboMATCH study is a national clinical trial to advance cancer treatment, using genetic testing to match advanced cancer patients with targeted treatments
(PRUnderground) August 10th, 2023
Intermountain Precision Genomics, part of the Intermountain Health system, and Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in genetic testing and precision medicine, will begin providing oncology test results that allow access to the ComboMATCH trials. ComboMATCH is a coordinated platform of clinical oncology trials sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health. Led by the NCI and the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN), ComboMATCH aims to help identify and show the efficacy of new anti-cancer drug combinations for patients with locally advanced or metastatic solid tumor cancers.
ComboMATCH includes a Patient Registration Trial led by ECOG-ACRIN, along with several treatment trials designed and led by the Alliance for Clinical Trials in Oncology, Children’s Oncology Group, ECOG-ACRIN Cancer Research Group, NRG Oncology, and SWOG Cancer Research Network. These groups are members of the NCI’s National Clinical Trials Network (NCTN).
In ComboMATCH, researchers in the NCTN groups will seek to improve cancer patient outcomes using new combinations of biomarker targeted therapies beyond the current standard of care. To be selected for the trial, combinations must show evidence they may be more effective than single therapy in treating cancer. Patients with locally advanced or metastatic cancer with eligible genetic testing completed through Intermountain or Myriad may have the opportunity to enroll in the ComboMATCH Patient Registration Trial (EAY191) to receive these types of combination therapies to target genetic mutations in their tumor cells and/or their germline.
“The ComboMATCH clinical trials are critically important for the advancement of precision oncology care, showcasing how genetic insights can help determine more targeted treatment decisions for patients with cancer,” said Michael Lyons, general manager of oncology, Myriad Genetics. “Our strong partnership with Intermountain enables us to continually collaborate and innovate together to provide comprehensive genomic profiling options that can help guide clinical care and improve outcomes for patients.”
In 2021, Myriad and Intermountain announced a collaboration on a comprehensive offering of germline and somatic tumor testing, known as Precise™ Oncology Solutions, leveraging the strengths of Myriad’s MyRisk® germline test and Intermountain’s somatic Theramap assay. Both the Myriad and Intermountain tests are now able to be used to identify patients that may be eligible for enrollment in a treatment study under ComboMATCH.
“Clinical trials like ComboMATCH present a unique opportunity for patients to get treatments, in this case, powerful targeted treatment combinations, that would otherwise not be available,” said Jason Gillman, Intermountain Precision Genomics Health Operations director. “This is especially valuable to the advanced cancer patients that TheraMap was designed to help.”
To learn more about ComboMATCH, visit https://ecog-acrin.org/combomatch.
For general information about ComboMATCH, visit https://www.cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/combomatch.
About Myriad Genetics
Myriad Genetics is a leading genetic testing and precision medicine company dedicated to advancing health and well-being for all. Myriad develops and offers genetic tests that help assess the risk of developing disease or disease progression and guide treatment decisions across medical specialties where genetic insights can significantly improve patient care and lower healthcare costs. For more information, visit www.myriad.com.
About Intermountain Health
Headquartered in Utah with locations in seven states and additional operations across the western U.S., www.intermountainhealth.org is a nonprofit system of 33 hospitals, 385 clinics, medical groups with some 3,900 employed physicians and advanced care providers, a health plans division called Select Health with more than one million members, and other health services. Helping people live the healthiest lives possible, Intermountain is committed to improving community health and is widely recognized as a leader in transforming healthcare by using evidence-based best practices to consistently deliver high-quality outcomes at sustainable costs. For more information or updates, see https://intermountainhealthcare.org/news.
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