UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                               ------------------
                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 2)

                           La Jolla Pharmaceutical Co.
                        ---------------------------------
                                (Name of issuer)

                     Common Stock, par value $0.01 per share
                       ---------------------------------
                         (Title of class of securities)

                                    503459109
                       ---------------------------------
                                 (CUSIP number)

                                December 31, 2001
                       ---------------------------------
             (Date of Event which requires filing of this Statement)

 Check the appropriate box to designate the rule pursuant to which
                            this schedule is filed:

                               [ ] Rule 13d-1 (b)
                               [X] Rule 13d-1 (c)
                               [ ] Rule 13d-1 (d)







-----------------------------                      -----------------------------
CUSIP No. 503459109                    13G              Page 2 of 10 Pages
-----------------------------                      -----------------------------

--------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank AG
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) [ ]
                                                                       (b) [ ]

--------------------------------------------------------------------------------
3        SEC USE ONLY

--------------------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
--------------------------------------------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ---------------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,923,800
                             ---------------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ---------------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,923,800
--------------------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,923,800*
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    [ ]
--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         8.3%**
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
--------------------------------------------------------------------------------


*    Included in this  figure are the  securities  reported  by  Deutsche  Asset
     Management  Europe  GmbH and DWS  Investment  GmbH on the  following  cover
     pages.

**   Included in this percentage are the  percentages of securities  reported by
     Deutsche  Asset  Management  Europe  GmbH  and DWS  Investment  GmbH on the
     following cover pages.







---------------------------------                  -----------------------------
CUSIP No. 503459109                    13G                 Page 3 of 10 Pages
---------------------------------                  -----------------------------


--------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Asset Management Europe GmbH
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) [ ]
                                                                       (b) [ ]

--------------------------------------------------------------------------------
3        SEC USE ONLY

--------------------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
--------------------------------------------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ---------------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,761,300
                             ---------------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ---------------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,761,300
--------------------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,761,300*
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    [ ]
--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         7.8%**
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC
--------------------------------------------------------------------------------



*    Included in this figure are the securities  reported by DWS Investment GmbH
     on the following cover page.

**   Included in this percentage are the  percentages of securities  reported by
     DWS Investment GmbH on the following cover page.








---------------------------------                  -----------------------------
CUSIP No. 503459109                    13G               Page 4 of 10 Pages
---------------------------------                  -----------------------------

--------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         DWS Investment GmbH
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) [ ]
                                                                       (b  [ ]

--------------------------------------------------------------------------------
3        SEC USE ONLY

--------------------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
--------------------------------------------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ---------------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      1,415,000
                             ---------------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ---------------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      1,415,000
--------------------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,415,000
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    [ ]
--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         4.0%
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         CO
--------------------------------------------------------------------------------








Item 1(a).     Name of Issuer:

               La Jolla Pharmaceutical Co. (the "Issuer")

Item 1(b).     Address of Issuer's Principal Executive Offices:

               The address of the Issuer's  principal  executive offices is 6455
Nancy Ridge Drive, San Diego, CA 92121, United States.

Item 2(a).     Name of Person Filing:

               This  statement is filed on behalf of Deutsche  Bank AG ("DBAG"),
Deutsche Asset Management Europe GmbH ("DWS Group"),  DWS Investment GmbH ("DWS"
and together with DBAG and DWS Group,  the "Reporting  Persons").  This Schedule
13G/A is being filed pursuant to Rule 13d-2(b).

Item 2(b).     Address of Principal Business Office or, if none, Residence:

               The  principal  place of  business  of DBAG is  Taunusanlage  12,
D-60325, Frankfurt am Main, Federal Republic of Germany.

               The principal  place of business of DWS Group is  Feldbergstrasse
22, 60323 Frankfurt, Federal Republic of Germany.

               The principal place of business of DWS is Grueneburgweg  113-115,
60612, Frankfurt, Federal Republic of Germany.

Item 2(c).     Citizenship:

               The  citizenship  of the  Reporting  Persons  is set forth on the
applicable cover page.

Item 2(d).     Title of Class of Securities:

               The title of the securities is common stock (the "Common Stock").

Item 2(e).     CUSIP Number:

               The CUSIP  number of the Common  Stock is set forth on each cover
page.

Item 3.        If this  statement  is  filed  pursuant  to  Rules  13d-1(b),  or
               13d-2(b) or (c), check whether the person filing is a:

               (a) [ ]  Broker or dealer registered under section 15 of the Act;

               (b) [ ]  Bank as defined in section 3(a)(6) of the Act;

               (c) [ ]  Insurance  Company as defined in section 3(a)(19) of the
                        Act;

               (d) [ ]  Investment  Company  registered  under  section 8 of the
                        Investment Company Act of 1940;



                                      -5-





               (e) [ ]  An  investment  adviser  in  accordance  with Rule 13d-1
                        (b)(1)(ii)(E);

               (f) [ ]  An  employee   benefit  plan,   or  endowment   fund  in
                        accordance with Rule 13d-1 (b)(1)(ii)(F);

               (g) [ ]  A parent holding company or control person in accordance
                        with Rule 13d-1 (b)(1)(ii)(G);

               (h) [ ]  A savings  association as defined in section 3(b) of the
                        Federal Deposit Insurance Act;

               (i) [ ]  A church plan that is excluded from the definition of an
                        investment   company  under  section   3(c)(14)  of  the
                        Investment Company Act of 1940;

               (j) [ ]  Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

               If this statement is filed pursuant to Rule 13d-1 (c), check this
box. [X]

Item 4.        Ownership.

               (a)      Amount beneficially owned:

                        Each of the  Reporting  Persons  owns the  amount of the
               Common Stock as set forth on the applicable cover page.

               (b)      Percent of class:

                        Each of the Reporting Persons owns the percentage of the
              Common Stock as set forth on the applicable cover page.

               (c)      Number of shares as to which such person has:

                        (i)  sole power to vote or to direct the vote:

                             Each of the Reporting Persons has the sole power to
                        vote or direct the vote of the Common Stock as set forth
                        on the applicable cover page.

                        (ii) shared power to vote or to direct the vote:

                             Each of the Reporting  Persons has the shared power
                        to vote or direct  the vote of the  Common  Stock as set
                        forth on the applicable cover page.

                        (iii)sole power to dispose or to direct the disposition
                             of:

                             Each of the Reporting Persons has the sole power to
                        dispose or direct the disposition of the Common Stock as
                        set forth on the applicable cover page.

                        (iv)shared power to dispose or to direct the disposition
                            of:



                                      -6-



                             Each of the Reporting  Persons has the shared power
                        to dispose or direct the disposition of the Common Stock
                        as set forth on the applicable cover page.

Item 5.        Ownership of Five Percent or Less of a Class.

               If this  statement  is being  filed to report the fact that as of
the date hereof the reporting persons have ceased to be the beneficial owners of
more than five percent of the class of securities check the following [x].1

Item 6.        Ownership of More than Five Percent on Behalf of Another Person.

               Investment  management  clients of each of the Reporting  Persons
have the ultimate right to any dividends from Common Stock and the proceeds from
the sale of Common Stock.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported on by the Parent  Holding
               Company.

               The  following  are  subsidiaries  of DBAG and/or DWS Group which
acquired Common Stock included in the figures on the cover pages: DWS Investment
GmbH,   DWS   Investment    S.A.    Luxemburg,    Deutsche   Asset    Management
Investmentgesellschaft mbH.

Item 8.        Identification and Classification of Members of the Group.

               Not applicable.

Item 9.        Notice of Dissolution of Group.

               Not applicable.

Item 10.       Certification.

               By signing  below I certify that, to the best of my knowledge and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.


---------------------
*   As of December 31, 2001, DWS Investment GmbH has ceased to be the beneficial
    owner of more than five percent of the class securities








                                    SIGNATURE

               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  February 12, 2002



                                                  DEUTSCHE BANK AG



                                                  By:/s/ Jeffrey A. Ruiz
                                                     --------------------------
                                                     Name:   Jeffrey A. Ruiz
                                                     Title:  Vice President




                                                  By:/s/ Margaret M. Adams
                                                     --------------------------
                                                     Name:   Margaret M. Adams
                                                     Title:  Director








                                                                       EXHIBIT 1



                Consent of Deutsche Asset Management Europe GmbH


               The undersigned agrees that the Schedule 13G executed by Deutsche
Bank AG to which this  statement is attached as an exhibit is filed on behalf of
Deutsche Bank AG, Deutsche Asset Management  Europe GmbH and DWS Investment GmbH
pursuant to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.

Dated:  February 12th, 2002



                                           DEUTSCHE ASSET MANAGEMENT
                                             EUROPE GMBH



                                           By:/s/ Dr. Dieter Eisele
                                              -----------------------------
                                              Name:    Dr. Dieter Eisele
                                              Title:   Global Head of Compliance



                                            By:/s/ Michaela Bundschuh
                                               ----------------------------
                                               Name:    Michaela Bundschuh
                                               Title:   Head Position Monitoring








                                                                       EXHIBIT 2




                         Consent of DWS Investment GmbH

               The undersigned agrees that the Schedule 13G executed by Deutsche
Bank AG to which this  statement is attached as an exhibit is filed on behalf of
Deutsche Bank AG, Deutsche Asset Management  Europe GmbH and DWS Investment GmbH
pursuant to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.

Dated:  February 12th, 2002



                                           DWS INVESTMENT GMBH



                                           By:/s/ Dr. Dieter Eisele
                                              ------------------------------
                                              Name:    Dr. Dieter Eisele
                                              Title:   Global Head of Compliance



                                           By:/s/ Michaela Bundschuh
                                              -----------------------------
                                              Name:    Michaela Bundschuh
                                              Title:   Head Position Monitoring