SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                Amendment No. 4

                   Under the Securities Exchange Act of 1934

                         La Jolla Pharmaceutical Company
                         -------------------------------
                                (Name of Issuer)

                                  Common Stock
                         ------------------------------
                         (Title of Class of Securities)

                                    503459109
                                 --------------
                                 (CUSIP Number)

                                 Hilary Strain
                       One Embarcadero Center, Suite 4050
                            San Francisco, CA 94111
                                 (415) 362-4022
          (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                December 29, 2004
                                -----------------
            (Date of Event which Requires Filing of this Statement)

        If the filing person has previously filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ]

        Check the following box if a fee is being paid with this  statement:  (A
fee is not required only if the reporting person:  (1) has a previous  statement
on file reporting beneficial ownership of more than five percent of the class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto  reporting  beneficial  ownership of five percent or less of such class.
(See Rule 13d-7).

        Note: Six copies of this  statement,  including all exhibits,  should be
filed with the  Commission.  See Rule  13d-1(a) for other parties to whom copies
are to be sent.

        * The  remainder  of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

        The  information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934,  as  amended  (the  "Exchange  Act") or  otherwise  subject  to the
liabilities  of that  section  of the  Exchange  Act but shall be subject to all
other provisions of the Exchange Act.

                        (Continued on following page(s))

                               Page 1 of 16 Pages





CUSIP NO. 503459109                                            13 D                                                   2 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alta Partners
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          California
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IA
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   3 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alta BioPharma Partners, L.P.
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          Delaware
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

       NUMBER OF          (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          PN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   4 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alta Embarcadero BioPharma Partners, LLC
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          California
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

       NUMBER OF          (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          CO
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   5 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          La Jolla Chase Partners (Alta Bio), LLC
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          Deleware
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

       NUMBER OF          (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          CO
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   6 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alta BioPharma Management, LLC
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          Deleware
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

       NUMBER OF          (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          CO
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   7 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alta/Chase BioPharma Management, LLC
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          WC
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          Deleware
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451     EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          CO
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                            13 D                                                   8 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Jean Deleage
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          AF
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          U.S.A.
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451     EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO. 503459109                                           13 D                                                   9 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Garrett Gruener
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          AF
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          U.S.A.
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO.  503459109                                           13 D                                                   10 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Daniel Janney
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          AF
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          U.S.A.
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING


        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451     EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO.  503459109                                           13 D                                                   11 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Alix Marduel
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          AF
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          U.S.A.
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                          2,826,451     EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP NO.  503459109                                           13 D                                                   12 of 16 Pages
                       
------------------------- ----------------------------------------------------------------------------------------------------------
(1)                       NAME OF REPORTING PERSON
                          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                          Guy Nohra
------------------------- ----------------------------------------------------------------------------------------------------------
(2)                       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                            (a) [ ]
                                                                                                                       (b) [X]
------------------------- ----------------------------------------------------------------------------------------------------------
(3)                       SEC USE ONLY

------------------------- ----------------------------------------------------------------------------------------------------------
(4)                       SOURCE OF FUNDS*

                          AF
------------------------- ----------------------------------------------------------------------------------------------------------
(5)                       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                          PURSUANT TO ITEMS 2(d) OR 2(e)                                                                   [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(6)                       CITIZENSHIP OR PLACE OF ORGANIZATION

                          U.S.A.
------------------------- ----------------------------------------------------------------------------------------------------------
                                        EXIT FILING

        NUMBER OF         (7)       SOLE VOTING POWER              0
         SHARES
      BENEFICIALLY        ----------------------------------------------------------------------------------------------------------
        OWNED BY          (8)       SHARED VOTING POWER            2,826,451
          EACH
       REPORTING
         PERSON           ----------------------------------------------------------------------------------------------------------
          WITH            (9)       SOLE DISPOSITIVE POWER         0

                          ----------------------------------------------------------------------------------------------------------
                          (10)      SHARED DISPOSITIVE POWER       2,826,451

------------------------- ----------------------------------------------------------------------------------------------------------
(11)                      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                           2,826,451    EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(12)                      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                           [ ]

------------------------- ----------------------------------------------------------------------------------------------------------
(13)                      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                          4.6%  EXIT FILING
------------------------- ----------------------------------------------------------------------------------------------------------
(14)                      TYPE OF REPORTING PERSON*

                          IN
------------------------- ----------------------------------------------------------------------------------------------------------

                                                *SEE INSTRUCTIONS BEFORE FILLING OUT!





Item 1. Security and Issuer.

        This  Statement  on Schedule D relates to the Common  Stock,  $0.001 par
value per share (the "Shares"),  of La Jolla Pharmaceutical  Company, a Delaware
corporation (the "Company").  The principal executive offices of the Company are
located at 6455 Nancy Ridge Drive, San Diego, California 92121.

        EXIT  FILING  --- The  outstanding  shares  of La  Jolla  Pharmaceutical
Company  increased  to  61,400,323,  resulting  in the shares  held by the funds
affiliated with Alta Partners to drop to 4.6% ownership. See Item 5 (a)


Item 2. Identity and Background.

        (a) This  Exit  Filing  is filed by Alta  BioPharma  Partners,  L.P.,  a
Delaware limited partnership ("Alta BioPharma"),  and Alta Embarcadero BioPharma
Partners,  LLC, a California limited liability company  ("Embarcadero LLC"), and
La Jolla Chase Partners (Alta Bio), LLC, a Delaware LLC ("La Jolla Alta Bio") by
virtue  of their  direct  beneficial  ownership  of  Shares,  by Alta  BioPharma
Management,  LLC, a Delaware limited liability company ("Alta  Management"),  by
virtue  of being the sole  general  partner  of Alta  BioPharma,  by  Alta/Chase
BioPharma  Management  LLC, a Delaware  limited  liability  company  (Alta/Chase
Management)  by virtue of being the sole  managing  director  of La Jolla  Chase
Partners (Alta Bio), LLC and by Alta Partners,  a California  corporation ("Alta
Partners"),  by  virtue  of  being  the  management  advisory  company  of these
entities.  Alta BioPharma,  Embarcadero LLC, La Jolla Alta Bio, Alta Management,
Alta/Chase  Management  and Alta  Partners are  collectively  referred to as the
"Reporting  Persons." Jean Deleage,  Garrett Gruener,  Dan Janney, Alix Marduel,
and Guy Nohra (the  "Partners") are the managing  directors of Alta  Management,
Alta/Chase   Management  and  officers  of  Alta  Partners.  By  virtue  of  the
relationships  described  above and their roles with Alta Partners,  each of the
Partners may be deemed to control Alta  Partners,  Alta/Chase  Management,  Alta
Management,  and,  therefore,  may be  deemed  to  possess  indirect  beneficial
ownership  of the Shares held by each  entity.  However,  none of the  Partners,
acting alone, has voting or investment power with respect to the Shares directly
beneficially  held by the  entities  and,  as a result,  the  Partners  disclaim
beneficial  ownership of the Shares directly  beneficially owned by each entity,
except to the extent of their pecuniary interest in each entity. Embarcadero LLC
is a side  company  that makes all  investments  pro rata to the capital of Alta
BioPharma  with all  allocations  made to its members based on paid-in  capital.
Certain of the Partners are members of  Embarcadero  LLC and certain  members of
Embarcadero LLC are affiliates of Alta Partners.

        (b) The principal executive offices of Alta BioPharma,  Embarcadero LLC,
La Jolla Alta Bio, Alta Management, Alta/Chase Management and Alta Partners, and
the business  address of each Partner,  are located at One  Embarcadero  Center,
Suite 4050, San Francisco, California 94111.

        (c) Alta  Partners  provides  investment  advisory  services  to several
venture capital funds.  Alta BioPharma,  La Jolla Alta Bio and Embarcadero LLC's
principal business is acting as venture capital investment vehicles.  Alta/Chase
Management  and Alta  Management's  principal  business  is acting  as  managing
director  of La Jolla  Alta Bio and Alta  BioPharma,  respectively.  Each of the
Partners' principal business is acting as a managing director of Alta Management
and Alta/Chase Management and as an officer of Alta Partners.

        (d) None of the Reporting  Persons or, to the knowledge of the Reporting
Persons, any of the Partners, has been convicted in a criminal proceeding in the
past five years (excluding traffic violations or similar misdemeanors).

                                 13 of 16 Pages


        (e) During the past five years, none of the Reporting Persons or, to the
knowledge of the Reporting Persons, none of the Partners, was a party to a civil
proceeding of a judicial or administrative  body of competent  jurisdiction as a
result of which such  person was or is  subject to a  judgment,  decree or final
order  enjoining  future  violations of, or prohibiting or mandating  activities
subject  to,  federal or state  securities  laws of finding any  violation  with
respect to such laws.

        (f) Alta  Partners is a  California  corporation.  Alta  BioPharma  is a
Delaware limited partnership.  Embarcadero LLC is a California limited liability
corporation.  La Jolla Alta Bio is a Delaware limited  liability  company.  Alta
Management and Alta/Chase  Management are Delaware limited liability  companies.
Each of the Partners is a citizen of the United States.


Item 3. Source and Amount of Funds or Other Consideration.

        N/A Exit  Filing  The  outstanding  shares  of La  Jolla  Pharmaceutical
Company  increased  to  61,400,323,  resulting  in the shares  held by the funds
affiliated with Alta Partners to drop to 4.6% ownership. See Item 5 (a).


Item 4. Purpose of Transaction.

        Exit Filing ---- See Item 5 (a)


Item 5. Interest in Securities of the Issuer.

        Exit Filing ------ The funds affiliated with Alta Partners  beneficially
own 2,826,451 shares or approximately  4.6% of the shares deemed  outstanding by
the Company  (61,400,323)  as of November 30, 2004. Alta BioPharma is the direct
beneficial owner of 1,756,883  shares of Common Stock or approximately  2.86% of
the shares deemed  outstanding  by the Company  (61,400,323)  as of November 30,
2004. La Jolla Alta Bio is the direct  beneficial  owner of 1,003,348  shares of
Common Stock or  approximately  1.63% of the shares  deemed  outstanding  by the
Company  (61,400,323)  as of November  30, 2004.  Embarcadero  LLC is the direct
beneficial owner of 66,220 shares of Common Stock or approximately  0.11% of the
shares deemed outstanding by the Company (61,400,323) as of November 30, 2004


Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer.

        Exit Filing


Item 7. Material to be Filed as Exhibits.

        None

                                 14 of 16 Pages


Signature

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Date: December 29, 2004

Alta Partners                           Alta BioPharma Partners, L.P.
By: /s/ Jean Deleage                    By: Alta BioPharma Management, LLC
--------------------                    Its General Partner
Jean Deleage, Vice President


Alta BioPharma Management, LLC          By: /s/ Daniel Janney
                                        ---------------------
                                        Daniel Janney, Managing Director


By: /s/ Jean Deleage                    La Jolla Chase Partners (Alta Bio), LLC
--------------------
Jean Deleage, Member

                                        By: Alta/Chase BioPharma Management, LLC
Alta/Chase BioPharma Management, LLC        Its Managing Member


By: /s/ Daniel Janney                   By: /s/ Daniel Janney
---------------------                   ---------------------
Daniel Janney, Member                   Daniel Janney, Member


Alta Embarcadero BioPharma Partners, LLC


By: /s/ Jean Deleage
--------------------
Jean Deleage, Member


/s/ Jean Deleage                                       /s/ Guy Nohra
----------------                                       -------------
Jean Deleage                                           Guy Nohra


/s/ Garrett Gruener                                    /s/ Alix Marduel
-------------------                                    ----------------
Garrett Gruener                                        Alix Marduel


/s/ Daniel Janney
-----------------
Daniel Janney

                                 15 of 16 Pages


                                    EXHIBIT A
                             Joint Filing Statement

        We, the  undersigned,  hereby  express our  agreement  that the attached
Schedule 13D is filed on behalf of each of us.

Date: December 29, 2004


Alta Partners                           Alta BioPharma Partners, L.P.

By: /s/ Jean Deleage                    By: Alta BioPharma Management, LLC
--------------------                    Its General Partner
Jean Deleage, Vice President


Alta BioPharma Management, LLC          By: /s/ Daniel Janney
                                        ---------------------
                                        Daniel Janney, Managing Director


By: /s/ Jean Deleage                    La Jolla Chase Partners (Alta Bio), LLC
--------------------
Jean Deleage, Member


                                        By: Alta/Chase BioPharma Management, LLC
Alta/Chase BioPharma Management, LLC        Its Managing Member


By: /s/ Daniel Janney                   By: /s/ Daniel Janney
---------------------                   ---------------------
Daniel Janney, Member                   Daniel Janney, Member

Alta Embarcadero BioPharma Partners, LLC


By: /s/ Jean Deleage
--------------------
Jean Deleage, Member


/s/ Jean Deleage                                       /s/ Guy Nohra
----------------                                       -------------
Jean Deleage                                           Guy Nohra


/s/ Garrett Gruener                                    /s/ Alix Marduel
-------------------                                    ----------------
Garrett Gruener                                        Alix Marduel


/s/ Daniel Janney
-----------------
Daniel Janney

                                 16 of 16 Pages