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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED
MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number 811-21180

Name of Fund: BlackRock Insured Municipal Income Investment Trust (BAF)

Fund Address: 100 Bellevue Parkway, Wilmington, DE 19809

Name and address of agent for service: Donald C. Burke, Chief Executive Officer, BlackRock Insured Municipal Income Investment Trust,
800 Scudders Mill Road, Plainsboro, NJ, 08536. Mailing address: P.O. Box 9011, Princeton, NJ, 08543-9011

Registrant’s telephone number, including area code: (800) 882-0052, Option 4

Date of fiscal year end: 08/31/2008

Date of reporting period: 09/01/2008 – 11/30/2008


Item 1 – Schedule of Investments


BlackRock Insured Municipal Income Investment Trust    
Schedule of Investments November 30, 2008 (Unaudited)   (Percentages shown are based on Net Assets)
        Par        
State   Municipal Bonds   (000)     Value  
California - 1.4%   Los Angeles County, California, Metropolitan Transportation Authority, Sales            
    Tax Revenue Refunding Bonds, Proposition C, VRDN,            
    Second Senior Series A, 7%, 7/01/20 (a)(b)(c) $ 1,500   $ 1,500,000  
Florida - 108.9%   Brevard County, Florida, Health Facilities Authority, Healthcare Facilities            
    Revenue Bonds (Health First Inc. Project), 5%, 4/01/36   1,750     1,061,025  
    Broward County, Florida, School Board, COP, Series A, 5.25%, 7/01/33 (d)   2,200     2,002,264  
    Colonial Country Club Community Development District, Florida, Special            
    Assessment Revenue Bonds, 6.40%, 5/01/33   3,730         2,960,613  
    Florida State Board of Education, Lottery Revenue Bonds, Series C,            
    5%, 1/01/22 (a)   8,640     8,224,675  
    Gainesville, Florida, Utilities System Revenue Bonds, Series A,            
    5%, 10/01/13 (d)(e)   2,500     2,758,050  
    Highlands County, Florida, Health Facilities Authority, Hospital Revenue            
    Bonds (Adventist Health System), Series A, 6%, 11/15/11 (e)   5,000     5,558,550  
    Hillsborough County, Florida, Aviation Authority, Revenue Refunding Bonds,            
    Series D, 5.50%, 10/01/26 (f)   1,295     1,277,530  
    Hillsborough County, Florida, IDA, PCR, Refunding (Tampa Electric Company            
    Project), Series B, 5.15%, 9/01/25   500     495,185  
    Hillsborough County, Florida, School Board, COP, Refunding, Series A,            
    5%, 7/01/25 (a)   7,580     7,234,125  
    Jacksonville, Florida, Excise Taxes Revenue Bonds, Series B,            
    5%, 10/01/26 (g)   8,000     6,795,360  
    Jacksonville, Florida, Health Facilities Authority, Hospital Revenue Bonds            
    (Baptist Medical Center Project), 5%, 8/15/37 (d)   1,000     857,700  
    Lake County, Florida, School Board, COP, Series A, 5%, 7/01/28 (g)   3,500     3,012,975  
    Miami-Dade County, Florida, School Board, COP, Refunding, Series B, 5.25%,            
    5/01/28 (f)   1,600     1,484,112  
    Miami-Dade County, Florida, School Board, COP, Refunding, Series B, 5.25%,            
    5/01/30 (f)   1,500     1,377,105  
    Miami-Dade County, Florida, Special Obligation Revenue Bonds,            
    Sub-Series A, 5.26%, 10/01/39 (a)(h)   10,000     1,160,300  
    Miami-Dade County, Florida, Special Obligation Revenue Bonds,            
    Sub-Series A, 5.26%, 10/01/40 (a)(h)   10,000     1,082,100  
    Miami-Dade County, Florida, Special Obligation Revenue Bonds,            
    Sub-Series B, 5.617%, 10/01/31 (a)(h)   26,935     5,664,431  
    Miami, Florida, Special Obligation Revenue Bonds (Street and Sidewalk            
    Improvement Program), 5.25%, 1/01/28 (a)   5,535     5,043,160  

 

  Portfolio Abbreviations            

To simplify the listings of portfolio holdings in the Schedule of Investments, the names and descriptions of many of the securities have been abbreviated according to the list below.

COP      Certificates of Participation   PCR Pollution Control Revenue Bonds
GO General Obligation Bonds   VRDN      Variable Rate Demand Notes
IDA Industrial Development Authority      

1



BlackRock Insured Municipal Income Investment Trust    
Schedule of Investments November 30, 2008 (Unaudited)   (Percentages shown are based on Net Assets)
        Par        
State   Municipal Bonds   (000)   Value  
    Orange County, Florida, Educational Facilities Authority, Educational            
    Facilities Revenue Bonds (Rollins College Project), 5.25%, 12/01/27 (g) $ 1,335   $ 1,235,182  
    Orange County, Florida, Health Facilities Authority, Hospital            
    Revenue Refunding Bonds (Orlando Regional Healthcare), Series B,            
    5.25%, 12/01/29 (d)   1,500     1,351,755  
    Orange County, Florida, Sales Tax Revenue Refunding Bonds, Series B,            
    5.125%, 1/01/32 (a)(i)   7,975     7,200,548  
    Orange County, Florida, School Board, COP, Series A, 5%, 8/01/27 (a)   2,000     1,742,500  
    Orange County, Florida, Tourist Development, Tax Revenue Refunding Bonds,            
    5%, 10/01/29 (g)   1,600     1,324,800  
    Orlando, Florida, Senior Tourist Development Tax Revenue Bonds (6th Cent            
    Contract Payments), Series A, 5.25%, 11/01/38 (f)   2,200     1,938,640  
    Orlando-Orange County Expressway Authority, Florida, Expressway Revenue            
    Bonds, Series A, 5%, 7/01/32 (d)   2,500     2,272,875  
    Palm Bay, Florida, Utility System Improvement Revenue Bonds,            
    5.47%, 10/01/28 (a)(h)(i)   4,015     1,086,017  
    Palm Bay, Florida, Utility System Improvement Revenue Bonds,            
    5.48%, 10/01/31 (a)(h)(i)   5,570     1,163,239  
    Pasco County, Florida, School Board, COP, Series A, 5%, 8/01/27 (a)(i)   5,815     5,066,319  
    Pinellas County, Florida, Health Facilities Authority Revenue Bonds (BayCare            
    Health System Inc.), 5.50%, 5/15/13 (e)   5,000     5,586,100  
    Polk County, Florida, Utility System Revenue Bonds, 5%, 10/01/29 (a)(i)   5,000     4,266,550  
    Saint Johns County, Florida, Ponte Vedra Utility System Revenue Bonds, 5%,            
    10/01/37 (d)   2,600     2,270,840  
    Sarasota County, Florida, Utilities System Revenue Refunding Bonds, Series C,            
    5.25%, 10/01/22 (a)(i)   2,845     2,839,253  
    Sunrise, Florida, Utility System Revenue Refunding Bonds,            
    5%, 10/01/28 (g)   5,000     4,299,550  
    Tohopekaliga, Florida, Water Authority, Utility System Revenue Bonds, Series            
    B, 5%, 10/01/23 (d)   1,000     967,370  
    Village Center Community Development District, Florida, Recreational            
    Revenue Bonds, Series A, 5%, 11/01/32 (a)   10,000     7,828,000  
    Village Community Development District Number 5, Florida, Special            
    Assessment Bonds, Series A, 6.50%, 5/01/33   3,350     3,158,782  
                113,647,580  
Illinois - 4.0%   Chicago, Illinois, Transit Authority, Capital Grant Receipts Revenue Bonds            
    (Federal Transit Administration Section 5309 Formula Funds), Series A, 6%,            
    6/01/26 (f)   1,300     1,330,420  
    Illinois State Toll Highway Authority Revenue Bonds, Series B,            
    5.50%, 1/01/33   3,000     2,876,280  
              4,206,700  
Minnesota - 5.3%   Minneapolis, Minnesota, Health Care System, Revenue Refunding Bonds            
    (Fairview Health Services), Series B, 6.50%, 11/15/38 (f)   5,680     5,498,183  
Nevada - 2.0%   Clark County, Nevada, Water Reclamation District, Limited Tax, GO,            
    6%, 7/01/38   2,000     2,036,340  

2



BlackRock Insured Municipal Income Investment Trust    
Schedule of Investments November 30, 2008 (Unaudited)   (Percentages shown are based on Net Assets)
        Par        
State   Municipal Bonds   (000)     Value   
North Carolina -   Charlotte-Mecklenburg Hospital Authority, North Carolina, Health Care            
4.3%   System Revenue Bonds (Carolinas Healthcare System), VRDN, Series J, 1.75%,            
    1/15/46 (b)(c)(d) $ 4,500   $ 4,500,000  
Texas - 2.9%   Harris County, Texas, Health Facilities Development Corporation, Hospital            
    Revenue Refunding Bonds (Memorial Hermann Healthcare System), Series B,            
    7.125%, 12/01/31   500     491,950  
    North Texas Tollway Authority, System Revenue Refunding Bonds,            
    First Tier, Series K-1, 5.75%, 1/01/38 (f)   1,500     1,407,540  
    Tarrant County, Texas, Cultural Education Facilities Financing Corporation,            
    Revenue Refunding Bonds (CHRISTUS Health), Series A,            
    6.50%, 7/01/37 (f)   1,200     1,130,388  
              3,029,878  
    Total Municipal Bonds - 128.8%           134,418,681  
    Municipal Bonds Transferred to Tender Option Bond Trusts (j)            
Florida - 36.3%   Florida State Board of Education, GO (Public Education Capital Outlay),            
    Series A, 5%, 6/01/27 (d)   9,000     8,602,200  
    Jacksonville, Florida, Sales Tax Revenue Bonds, 5%, 10/01/27 (a)   3,930     3,754,211  
    Jacksonville, Florida, Transit Revenue Bonds, 5%, 10/01/31 (a)   9,500     8,621,085  
    Palm Beach County, Florida, School Board, COP, Refunding, Series D,            
    5%, 8/01/28 (d)   9,190     8,363,359  
    Pinellas County, Florida, Sewer Revenue Bonds, 5%, 10/01/32 (d)   9,500     8,568,495  
    Total Municipal Bonds Transferred to Tender Option Bond Trusts - 36.3%         37,909,350  
    Total Long-Term Investments (Cost - $191,647,951) - 165.1%         172,328,031  
    Short-Term Securities   Shares        
    CMA Florida Municipal Money Fund, 0.84% (k)(l)   303,147     303,147  
    Total Short-Term Securities (Cost - $303,147) - 0.3%         303,147  
    Total Investments (Cost - $191,951,098*) - 165.4%         172,631,178  
    Other Assets Less Liabilities - 1.5%         1,568,194  
    Liability for Trust Certificates, Including Interest Expense and            
    Fees Payable - (24.4)%         (25,459,325 )
    Preferred Shares, at Redemption Value - (42.5)%         (44,386,730 )
    Net Assets Applicable to Common Shares - 100.0%       $ 104,353,317  

*

The cost and unrealized appreciation (depreciation) of investments as of November 30, 2008, as computed for federal income tax purposes, were as follows:


         Aggregate cost   $ 166,616,783    
  Gross unrealized appreciation   $ 1,551,367    
  Gross unrealized depreciation     (20,756,970 )  
  Net unrealized depreciation   $      (19,205,603 )  

(a)     

MBIA Insured.

(b)

Variable rate security. Rate shown is as of report date. Maturity shown is the final maturity date.

(c)

Security may have a maturity of more than one year at the time of issuance, but has variable rate and demand features that qualify it as a short-term security.

(d)

FSA Insured.

 

3



BlackRock Insured Municipal Income Investment Trust
Schedule of Investments November 30, 2008 (Unaudited)

(e)     

U.S. government securities, held in escrow, are used to pay interest on this security as well as to retire the bond in full at the date indicated, typically at a premium to par.

(f)

Assured Guaranty Insured.

(g)

AMBAC Insured.

(h)

Represents a zero-coupon bond. Rate shown reflects the effective yield at the time of purchase.

(i)

FGIC Insured.

(j)

Securities represent bonds transferred to a tender option bond trust in exchange for which the Trust acquired residual interest certificates. These securities serve as collateral in a financing transaction.

(k)

Investments in companies considered to be an affiliate of the Trust, for purposes of Section 2(a)(3) of the Investment Company Act of 1940, were as follows:

 
             Net    
  Affiliate   Activity             Income
  CMA Florida Municipal Money Fund   (3,975,598)   $      27,706
(l)     

Represents the current yield as of report date.

  • Effective September 1, 2008, the Trust adopted Financial Accounting Standards Board Statement of Financial Accounting Standards No. 157, "Fair Value Measurements" ("FAS 157"). FAS 157 clarifies the definition of fair value, establishes a framework for measuring fair values and requires additional disclosures about the use of fair value measurements. Various inputs are used in determining the fair value of investments, which are as follows:

  • Level 1 - price quotations in active markets/exchanges for identical securities

  • Level 2 - other observable inputs (including, but not limited to: quoted prices for similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the assets or liabilities (such as interest rates, yield curves, volatilities, prepayment speeds, loss severities, credit risks, and default rates) or other market- corroborated inputs)

  • Level 3 - unobservable inputs based on the best information available in the circumstance, to the extent observable inputs are not available (including the Trust's own assumption used in determining the fair value of investments)

The inputs or methodology used for valuing securities are not necessarily an indication of the risk associated with investing in those securities. For information about the Trust's policy regarding valuation of investments and other significant accounting policies, please refer to the Trust's most recent financial statements as contained in its annual report.

The following table summarizes the inputs used as of November 30, 2008 in determining the fair valuation of the Trusts' investments:

         Valuation   Investments in  
  Inputs   Securities  
  Level 1   $ 303,147   
  Level 2     172,328,031  
  Level 3     -  
  Total   $ 172,631,178  

4


Item 2 – Controls and Procedures
 
2(a) – The registrant’s principal executive and principal financial officers or persons performing similar functions have concluded that the registrant’s disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the “1940 Act”)) are effective as of a date within 90 days of the filing of this report based on the evaluation of these controls and procedures required by Rule 30a-3(b) under the 1940 Act and Rule 13a-15(b) under the Securities Exchange Act of 1934, as amended.
 
2(b) – There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act) that occurred during the registrant’s last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant’s internal control over financial reporting.
 
Item 3 – Exhibits
 
  Certifications – Attached hereto
 
  Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 
  BlackRock Insured Municipal Income Investment Trust
 
  By:
/s/ Donald C. Burke
  Donald C. Burke
  Chief Executive Officer of
  BlackRock Insured Municipal Income Investment Trust
 
  Date:      January 20, 2009
 
  Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.
 
  By:
/s/ Donald C. Burke
  Donald C. Burke
  Chief Executive Officer (principal executive officer) of
  BlackRock Insured Municipal Income Investment Trust
 
  Date:      January 20, 2009
 
  By:
/s/ Neal J. Andrews
  Neal J. Andrews
  Chief Financial Officer (principal financial officer) of
  BlackRock Insured Municipal Income Investment Trust
 
  Date:      January 20, 2009