UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of report (Date of earliest event reported): DECEMBER 14, 2006
                                                         -----------------------

                               ENZO BIOCHEM, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    NEW YORK
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                 (State or Other Jurisdiction of Incorporation)

             001-09974                                     13-2866202
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        (Commission File Number)               (IRS Employer Identification No.)

           527 MADISON AVENUE
           NEW YORK, NEW YORK                                         10022
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(Address of Principal Executive Offices)                           (Zip Code)

                                 (212) 583-0100
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              (Registrant's Telephone Number, Including Area Code)


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          (Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

|_|  Written communications pursuant to Rule 425 under the Securities Act
     (17 CFR 230.425)

|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act
     (17 CFR 240.14a-12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))






ITEM 1.01.        ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

         On December 14, 2006, Enzo Biochem, Inc. entered into a Placement Agent
Agreement with Lazard Capital Markets LLC as exclusive placement agent relating
to a proposed "registered direct" offering of shares of Enzo's common stock. A
copy of the Placement Agent Agreement is filed as Exhibit 1.1 to this Current
Report and is incorporated herein by reference. The closing for the sale of
shares of common stock is expected to take place on December 20, 2006, subject
to the satisfaction of customary closing conditions. Enzo will pay the placement
agent an aggregate fee equal to 5.5% of the gross proceeds of the offering,
equal to approximately $2,530,000 million.

         In addition, on December 14, 2006, Enzo entered into definitive
Subscription Agreements with certain investors relating to the sale of an
aggregate of 3,285,715 shares of common stock for a purchase price of $14.00 per
share. A copy of the form of Subscription Agreement is filed as Exhibit 10.1 to
this Current Report and is incorporated herein by reference.

         The shares of common stock being offered by Enzo in this offering were
registered under an existing shelf registration statement on Form S-3
(Registration No. 333-138417), which was declared effective by the Securities
and Exchange Commission on December 8, 2006.

ITEM 8.01         OTHER EVENTS.

         On December 15, 2006, Enzo issued a press release announcing the
pricing of the offering of common stock described above. A copy of this press
release is furnished as Exhibit 99.1 to this Current Report.


ITEM 9.01.       EXHIBITS.

(c) EXHIBITS.

EXHIBIT NO.          DESCRIPTION
1.1                  Placement Agent Agreement, dated December 14, 2006,
                     between Enzo Biochem, Inc. and Lazard Capital Markets LLC.

10.1                 Form of Subscription Agreement.

99.1                 Press release dated December 15, 2006.





                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.

                                           ENZO BIOCHEM, INC.


Date:  December 15, 2006                   By:   /s/ Elazar Rabbani
                                                 -------------------------------
                                                 Dr. Elazar Rabbani, Ph.D.
                                                 Chairman of the Board and Chief
                                                 Executive Officer