UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

     Date of report (Date of earliest event reported):  SEPTEMBER 15, 2006
                                                      --------------------------

                               ENZO BIOCHEM, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    NEW YORK
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                 (State or Other Jurisdiction of Incorporation)

            001-09974                                   13-2866202
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    (Commission File Number)                 (IRS Employer Identification No.)

              60 EXECUTIVE BOULEVARD
               FARMINGDALE, NEW YORK                                  11735
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     (Address of Principal Executive Offices)                      (Zip Code)

                                 (631) 755-5500
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              (Registrant's Telephone Number, Including Area Code)


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          (Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

|_|  Written communications pursuant to Rule 425 under the Securities Act (17
CFR 230.425)

|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))



ITEM 1.01.     ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

         Enzo Biochem, Inc. (the "Company"), along with its subsidiary Enzo Life
Sciences,  Inc. and Yale  University,  entered into a Settlement  Agreement  and
Release,  effective  September 15, 2006 (the  "Agreement"),  with  Sigma-Aldrich
Corp., Sigma Chemical Company, Inc.,  Sigma-Aldrich Co. and Sigma-Aldrich,  Inc.
(collectively, "Sigma").

         As a result of the Agreement,  the Company will recognize $2,000,000 in
the fiscal quarter ending October 31, 2006.

         The  Agreement  is filed with this  current  report as Exhibit 10.1 and
incorporated herein by reference.

ITEM 9.01.     FINANCIAL STATEMENTS AND EXHIBITS.

(d)   EXHIBITS.

Exhibit No.       Description
-----------       -----------

10.1              Settlement  Agreement  and Release,  effective  September  15,
                  2006, among Enzo Biochem, Inc., Enzo Life Sciences, Inc., Yale
                  University, Sigma-Aldrich Corp., Sigma Chemical Company, Inc.,
                  Sigma-Aldrich Co. and Sigma-Aldrich, Inc.*


*        Certain confidential portions of this exhibit were omitted and provided
         separately  to the  Securities  and Exchange  Commission  pursuant to a
         request for confidential treatment.




                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended,  the  registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.


                                       ENZO BIOCHEM, INC.



Date:  September 21, 2006              By: /s/ BARRY WEINER
                                           -------------------------------------
                                           Barry Weiner
                                           President and Chief Financial Officer




                                  EXHIBIT INDEX


Exhibit No.       Description
-----------       -----------

10.1              Settlement  Agreement  and Release,  effective  September  15,
                  2006, among Enzo Biochem, Inc., Enzo Life Sciences, Inc., Yale
                  University, Sigma-Aldrich Corp., Sigma Chemical Company, Inc.,
                  Sigma-Aldrich Co. and Sigma-Aldrich, Inc.*


*        Certain confidential portions of this exhibit were omitted and provided
         separately  to the  Securities  and Exchange  Commission  pursuant to a
         request for confidential treatment.