UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------


                                    FORM 11-K

    FOR ANNUAL REPORTS OF EMPLOYEE STOCK REPURCHASE SAVINGS AND SIMILAR PLANS
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


(MARK ONE)


|X|  ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2005

                                       OR

|_|  TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM ______________ TO ______________

                        COMMISSION FILE NUMBER 001-09974

                                   ----------

             Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

     (Full title of the plan and the address of the plan, if different from that
of the issuer named below:)

     ENZO BIOCHEM, INC., 60 EXECUTIVE BOULEVARD, FARMINGDALE, NY 11735

     (Name of issuer of the securities held pursuant to the plan and the address
of its principal executive office)







                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                              FINANCIAL STATEMENTS

                           DECEMBER 31, 2005 AND 2004




                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                                TABLE OF CONTENTS


                                                                     PAGE
                                                                  ----------

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM               1

FINANCIAL STATEMENTS:

      Statements of Net Assets Available for Benefits
        December 31, 2005 and 2004                                    2

      Statement of Changes in Net Assets Available for Benefits       3
        For the year ended December 31, 2005

      Notes to Financial Statements                                  4-7

SUPPLEMENTAL SCHEDULE FOR THE YEAR ENDED
DECEMBER 31, 2005:

      Schedule H, Item 4i -
      Schedule of Assets Held at End of Year                          8

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM          Exhibit 23



             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



To the Trustees of
Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan


We have audited the accompanying  statement of net assets available for benefits
of Enzo Biochem,  Inc. Salary  Reduction  Profit Sharing Plan (the "Plan") as of
December 31, 2005 and the related  statement of changes in net assets  available
for  benefits  for the year  then  ended.  These  financial  statements  are the
responsibility  of the Plan's  management.  Our  responsibility is to express an
opinion on these financial statements based on our audit.

We conducted our audit in accordance with generally  accepted auditing standards
as established by the Auditing Standards Board (United States) and in accordance
with the  standards of the Public  Company  Accounting  Oversight  Board (United
States).  Those  standards  require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  The Plan is not required to have, nor were we engaged to perform,
an audit of its internal  control over financial  reporting.  Our audit included
consideration  of  internal  control  over  financial  reporting  as a basis for
designing audit  procedures that are appropriate in the  circumstances,  but not
for the  purpose of  expressing  an opinion on the  effectiveness  of the Plan's
internal  control  over  financial  reporting.  Accordingly,  we express no such
opinion. An audit also includes examining,  on a test basis, evidence supporting
the  amounts  and  disclosures  in  the  financial  statements,   assessing  the
accounting principles used and significant estimates made by management, as well
as evaluating the overall financial statement presentation.  We believe that our
audit provides a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2005 and the changes in net assets  available  for benefits for the
year ended December 31, 2005 in conformity with accounting  principles generally
accepted in the United States of America.

Our audit was  conducted  for the  purpose  of  forming  an opinion on the basic
financial statements taken as a whole. The supplemental  schedule of assets held
for investment  purposes at the end of the year, is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting and Disclosure  under the Employee  Retirement  Income
Security Act of 1974. The  supplemental  schedule is the  responsibility  of the
Plan's management.  The supplemental schedule has been subjected to the auditing
procedures  applied in the audit of the basic  financial  statements and, in our
opinion,  is fairly  stated in all  material  respects  in relation to the basic
financial statements taken as a whole.

The 2004 statement of net assets available for benefits and statement of changes
in net assets  available for benefits of Enzo  Biochem,  Inc.  Salary  Reduction
Profit  Sharing Plan was reported on by other  auditors,  whose report dated May
23, 2005, expressed an opinion that such financial statements present fairly, in
all material  respects the net assets  available for benefits and changes in net
assets  available for benefits of Enzo Biochem,  Inc.  Salary  Reduction  Profit
Sharing Plan as of and for the year ended  December 31, 2004 in conformity  with
accounting principles generally accepted in the United States of America.


June 23, 2006
Woodbury, New York




                                                                          Page 2


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                 STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS

                                  DECEMBER 31,





                                              2005                  2004
                                        ---------------       --------------

ASSETS

Cash                                    $        6,008        $       13,334
                                        --------------        --------------
Investments at fair value:
    Mutual funds                             8,315,380             7,243,623
    Common stock                             1,643,178             2,289,847
    Common/Collective trusts                   783,325               522,263
                                        --------------        --------------
                                            10,741,883            10,055,733
                                        --------------        --------------
Receivables:
    Employer's contributions                   402,304               351,579
    Participants' contributions                 28,908                19,258
                                        --------------        --------------
                                               431,212               370,837
                                        --------------        --------------

Loans receivable - participants                233,700               218,831
                                        --------------        --------------

TOTAL ASSETS                                11,412,803            10,658,735
                                        --------------        --------------

LIABILITIES

  Benefit claims payable                           --                  6,333
                                        --------------        --------------

TOTAL LIABILITIES                                  --                  6,333
                                        --------------        --------------

NET ASSETS AVAILABLE FOR BENEFITS       $   11,412,803        $   10,652,402
                                        ==============        ==============


See notes to financial statements.




                                                                          Page 3


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS

                      FOR THE YEAR ENDED DECEMBER 31, 2005





Additions to (reductions of) net assets
 attributed to:
  Participants' contributions                                    $    1,037,669
  Employer's contributions                                              402,304
  Interest on loans to participants                                      12,790
  Net appreciation (depreciation) in fair
   value of investments:
      Mutual funds                          $    677,979
      Common stock                              (947,704)              (269,725)
                                            -------------        ---------------

         Total additions                                              1,183,038
                                                                 --------------

Deductions from net assets attributed to:
  Benefits paid to participants                                         391,847
  Administrative expenses                                                30,790
                                                                 --------------

         Total deductions                                               422,637
                                                                 --------------

Net increase in net assets                                              760,401

Net assets available for benefits,
  beginning of year                                                  10,652,402
                                                                 --------------

Net assets available for benefits,
  end of year                                                    $   11,412,803
                                                                 ==============


See notes to financial statements.





                                                                          Page 4

                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS


NOTE 1:      PLAN DESCRIPTION

             The  following   description  of  the  Enzo  Biochem,  Inc.  Salary
             Reduction  Profit Sharing  Plan ("the Plan")  provides only general
             information.  Participants  should refer to the Plan Agreement,  as
             amended, for a more complete description of the Plan's provisions.

             GENERAL

             The Plan is a defined  contribution plan covering all eligible full
             time  employees of Enzo Biochem,  Inc.,  the Plan Sponsor,  and its
             wholly  owned   subsidiaries,   Enzo  Clinical  Labs,   Inc.,  Enzo
             Therapeutics, Inc. and Enzo Life Sciences, Inc. (collectively,  the
             "Company")  who have  completed  three  months of service  and have
             attained age twenty-one.

             The Plan is subject to the  provisions  of the Employee  Retirement
             Income Security Act of 1974 (ERISA).

             CONTRIBUTIONS

             Eligible employee participants can elect to defer up to the maximum
             amount  permitted  by the  Internal  Revenue  Code  for  each  year
             ($14,000 in 2005 and $13,000 in 2004).  Effective  January 1, 2002,
             catch-up contributions are also permitted for participants who have
             attained age 50 by December 31st, in accordance with Section 414(v)
             of the Code,  in an amount up to a maximum  of $4,000 in 2005,  and
             $3,000 in 2004, bringing those participants'  statutory  limitation
             to $18,000 for 2005 and $16,000 for 2004.

             In   addition,   the  Company  will   contribute   to  the  Plan  a
             discretionary   matching   contribution   equal   to   50%  of  the
             participant's 401(k) contribution,  not to exceed 50% of 10% of the
             participant's annual compensation.  Participants who have completed
             a year of service during the plan year and are actively employed as
             of the last day of the plan year shall be deemed  eligible to share
             in the  matching  contribution  for the year.  In 2005 and 2004 the
             total   matching   contributions   were   $402,304   and   $351,579
             respectively, in the form of Enzo Biochem Inc. common stock.

             PARTICIPANTS' ACCOUNTS

             Contributions  are invested in a choice of thirteen mutual funds, a
             benefit  responsive  investment  contract,  and the common stock of
             Enzo Biochem,  Inc.  Contribution  selections are designated by the
             participants.  Each  participant's  account  is  credited  with the
             participant's  contribution  and  allocations  of (a) the Company's
             matching  contribution and, (b) Plan earnings,  and charged with an
             allocation of  administrative  expenses.  Allocations  are based on
             participant  compensation  or account  balances,  as  defined.  The
             benefit to which a participant  is entitled is the benefit that can
             be provided from the participant's vested account.

             VESTING

             Participants'  contributed funds arising from salary reductions and
             the earnings thereon, are fully vested at all times. Vesting in the
             Company's  matching  contribution and earnings thereon,  is ratable
             over four years of service.  Any forfeited amounts shall be applied
             to reduce the Company's future  contributions.  For the years ended
             December  31,  2005 and  2004,  the  Company's  contributions  were
             reduced  by  forfeitures  of  approximately   $11,200  and  $7,000,
             respectively.





                                                                          Page 5


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 1:      PLAN DESCRIPTION (CONTINUED)

             LOANS TO PARTICIPANTS

             Participants  may borrow  from their  401(k)  accounts a minimum of
             $1,000 up to a maximum of 50% of their  vested  account  balance or
             $50,000. Participants are entitled to borrow from their account for
             a maximum  loan term of five years  unless the proceeds are used to
             acquire a principal  residence in which case it may exceed 5 years.
             The loans are secured by the  participant's  vested account balance
             and bear a reasonable  rate of interest.  Principal and interest is
             paid ratably through payroll deductions.

             PAYMENT OF BENEFITS

             On termination  of service due to death,  disability or retirement,
             participants  may elect to receive an amount  equal to the value of
             the vested interest in their account in either a lump sum amount or
             in various annuity options. For termination of service due to other
             reasons, a participant may receive the value of the vested interest
             in their account as a lump sum  distribution.  Benefits are payable
             in the form of cash or property.

             OPERATING EXPENSES

             Certain  operating  expenses  of the Plan are  absorbed by the Plan
             Sponsor.

NOTE 2:      SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

             The Plan's  financial  statements  have been prepared in conformity
             with accounting  principles generally accepted in the United States
             of America and under the accrual basis method of accounting.

             The Plan's  investments  are  stated at fair  value  except for its
             benefit responsive  investment contract which is valued at contract
             value  (Note  4).   Investment   earnings  are  reinvested  in  the
             respective   funds.   Investment   earnings   include   the  Plan's
             proportionate share of realized gains and losses on the disposal of
             investments,  and appreciation or depreciation in the fair value of
             the underlying  investments comprising the respective mutual funds.
             All purchases and sales are recorded on a trade date basis.

             The  Plan  presents  in the  statement  of  changes  in  net  asset
             available for benefits,  the net  appreciation in fair value of its
             investments, which consists of the realized gains or losses and the
             unrealized appreciation (depreciation) on those investments.

             The  preparation  of the financial  statements  in conformity  with
             accounting  principles  generally  accepted in the United States of
             America requires  management to make estimates and assumptions that
             affect   reported   amounts  and   disclosures   in  the  financial
             statements. Actual results could differ from those estimates.

             Certain accounts in the prior-year  financial  statements have been
             reclassified   for   comparative   purposes  to  conform  with  the
             presentation    in    the   current-year   financial    statements.
             Collective/Common  trusts have been  reclassified from mutual funds
             for the years ended December 31, 2005 and 2004.




                                                                          Page 6

                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS




NOTE 3:      INVESTMENTS

             The  following  table  presents the fair values,  as  determined by
             quoted market price, of the investments except for the Metropolitan
             Life Stable Value Contract, which is presented at contract value:




                                                                                2005                    2004
                                                                          ---------------          -------------
                                                                                          

             Enzo Biochem, Inc.*                                            $   1,643,178          $   2,289,847
             American Century Government Bond                               $     266,421          $     188,121
             American Funds AMCAP Fund CL A*                                $     644,819          $      26,459
             American Funds American Balanced Fund CL A*                    $   1,436,346          $   1,318,378
             American Funds Europacific Growth CL A*                        $   1,410,406          $   1,174,844
             American Funds Washington Mutual
               Investors Fund CL A*                                         $   2,299,358          $   2,117,271
             Baron Growth Fund                                              $     112,259          $      46,874
             Calamos Growth Fund CL A                                       $     470,628          $           -
             Fidelity Contrafund*                                           $     823,150          $     673,476
             Fidelity Spartan US Equity Index Fund                          $     155,716          $     178,479
             Freemont Bond Fund                                             $      75,272          $       6,481
             Hotchkis & Wiley Mid Cap Value CL 1                            $     193,168          $      26,381
             Neuberger & Berman Genesis Fund Trust                          $     378,051          $     319,346
             Metropolitan Life Stable Value Contract (Note 4)*              $     783,325          $     522,263
             Royce Total Return                                             $      49,786          $           -
             Federated Kaufmann Fund K                                      $           -          $     471,276
             Janus Fund                                                     $           -          $     696,237


             * Denotes  investments  representing  5% or  more of net assets
               available for benefits at December 31, 2005.

NOTE 4:      INVESTMENT CONTRACT WITH INSURANCE COMPANY

             The Plan has a benefit-responsive  investment contract with MetLife
             Trust Company,  National Association  (MetLife).  MetLife maintains
             the contributions in separate  accounts.  The accounts are credited
             with  earnings  on  the  underlying  investments  and  charged  for
             participant  withdrawals and administrative  expenses. The contract
             is  included  in the  financial  statements  at  contract  value as
             reported  to the Plan by  Counsel  Trust  Company.  Contract  value
             represents  contributions  made under the contract,  plus earnings,
             less   participant   withdrawals   and   administrative   expenses.
             Participants  may  ordinarily  direct the withdrawal or transfer of
             all or a portion of their investment at contract value.

             There are no reserves against contract value for credit risk of the
             contract  issuer or  otherwise.  The  average  yield and  crediting
             interest rates were  approximately 4.1% and 3.7% for 2005 and 2004,
             respectively.






                                                                          Page 7


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 5:      RIGHT TO TERMINATE PLAN

             Although it has not  expressed any intent to do so, the Company has
             the right under the Plan to discontinue  its  contributions  at any
             time and to terminate the Plan subject to the provisions of ERISA.

NOTE 6:      TAX STATUS

             The Plan obtained its latest  determination letter in February 2002
             in which the Internal  Revenue  Service stated that the Plan was in
             compliance with the applicable requirements of the Internal Revenue
             Code. The Plan has been amended since  receiving the  determination
             letter.  However, the plan administrator and the plan's tax counsel
             believe that the plan is currently  designed and being  operated in
             compliance with the applicable requirements of the Internal Revenue
             Code.

NOTE 7:      RELATED PARTY TRANSACTIONS

             During  2005,  the Plan  purchased  shares of common  stock in Enzo
             Biochem,  Inc., the parent  company of the Plan sponsor,  at market
             prices totaling  approximately  $140,000. In addition,  shares were
             sold, at market prices totaling approximately $263,000. At December
             31, 2005 and 2004 the Plan held Enzo  Biochem,  Inc.  common  stock
             with a fair value of $1,643,178 and $2,289,847, respectively.

             Fees  paid  by the  Plan to the  third  party  Plan  administrators
             amounted to $28,690 for the year ended December 31, 2005.

NOTE 8:      RISKS AND UNCERTAINTIES

             The Plan  invests  in  various  investment  securities.  Investment
             securities  are  exposed to  various  risk such as  interest  rate,
             market,  and credit risks. Due to the level of risk associated with
             certain investment  securities,  it is at least reasonably possible
             that changes in the values of investment  securities  will occur in
             the  near  term and  that  such  changes  could  materially  affect
             participants'  account  balances  and the  amounts  reported in the
             statement of net assets available for benefits.

NOTE 9:      SUBSEQUENT EVENTS - PLAN AMENDMENTS

             Effective  April 15, 2006, the Company  amended the Plan to allow a
             Plan  participant  to elect to  classify  all or part of his or her
             elective deferrals as a Roth 401(k) deferral.

             Effective   June  1,  2006,   the   Company   amended   the  Plan's
             participant's  salary reduction  election.  The amendment  requires
             participants  to make an initial salary  deferral  election,  or an
             election  to receive  cash in lieu of a salary  deferral  election,
             within  30  days  after   entering   the  Plan.   A   participant's
             compensation  will  automatically  be reduced by 3%,  which will be
             considered to be the Participant's salary reduction election if the
             Participant  does not elect to defer a portion of  compensation  or
             elect to receive cash in lieu of making a salary deferral election.





                                                                          Page 8

                               ENZO BIOCHEM, INC.
                              SALARY REDUCTION PLAN

                               SCHEDULE H, ITEM 4I
                     SCHEDULE OF ASSETS HELD AT END OF YEAR

                               E.I.N. # 13-2869332
                                   PLAN # 001

                          YEAR ENDED DECEMBER 31, 2005




                                                                       DESCRIPTION OF
                                                                    INVESTMENT INCLUDING
                          IDENTITY OF ISSUE,                        MATURITY DATE, RATE
                         BORROWER, LESSOR OR                      OF INTEREST, COLLATERAL,                  CURRENT VALUE
                            SIMILAR PARTY                          PAR OR MATURITY VALUE           COST           (e)
 (a)                         (b)                                           (c)                      (d)    ---------------
 ---    --------------------------------------------              -------------------------        -----
                                                                                                
  *     Enzo Biochem, Inc.                                            Common Stock                          $   1,643,178
        American Century Government Bond                              Mutual Fund                           $     266,421
        American Funds AMCAP Fund CL A                                Mutual Fund                           $     644,819
        American Funds American Balanced Fund CL A                    Mutual Fund                           $   1,436,346
        American Funds Europacific Growth CL A                        Mutual Fund                           $   1,410,406
        American Funds Washington Mutual
          Investors Fund CL A                                         Mutual Fund                           $   2,299,358
        Baron Growth Fund                                             Mutual Fund                           $     112,259
        Calamos Growth Fund CL A                                      Mutual Fund                           $     470,628
        Fidelity Contrafund                                           Mutual Fund                           $     823,150
        Fidelity Spartan US Equity Index Fund                         Mutual Fund                           $     155,716
        Freemont Bond Fund                                            Mutual Fund                           $      75,272
        Hotchkis & Wiley Mid Cap Value CL 1                           Mutual Fund                           $     193,168
        Neuberger & Berman Genesis Fund Trust                         Mutual Fund                           $     378,051
        Metropolitan Life Ins Co.                                   Guaranteed Investment                   $     783,325
                                                                          Contract
        Royce Total Return                                            Mutual Fund                           $      49,786
        Participant Loans                                             5.00% - 9.50%                   -0-   $     233,700


        * Party-in-interest









See Independent Auditors' Report.


                                   SIGNATURES

     THE PLAN. Pursuant to the requirements of the Securities Exchange Act of
1934, a trustee of the below named employee benefit plan has duly caused this
annual report to be signed on its behalf by the undersigned hereunto duly
authorized.

Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

               Date: June 27, 2006

                                            /s/ Herbert Bass
                                            -----------------------------
                                            By: Herbert Bass
                                                Trustee