As filed with the Securities and Exchange Commission on January 14, 2002 REGISTRATION NO. 333 - SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 -------------------- FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ------------------- EPIX MEDICAL, INC. (Exact name of registrant as specified in its charter) DELAWARE 04-3030815 (State or other jurisdiction of (I.R.S.Employer incorporation or organization) Identification No.) 71 ROGERS STREET CAMBRIDGE, MASSACHUSETTS 02142 TELEPHONE: (617) 250-6000 (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) ------------------- MICHAEL D. WEBB CHIEF EXECUTIVE OFFICER EPIX MEDICAL, INC. 71 ROGERS STREET CAMBRIDGE, MASSACHUSETTS 02142 (617) 250-6000 (Name, address, including zip code, and telephone number, including area code, of agent for service) -------------------- COPY TO: WILLIAM T. WHELAN, ESQ. MINTZ, LEVIN, COHN, FERRIS, GLOVSKY AND POPEO, P.C. ONE FINANCIAL CENTER BOSTON, MA 02111 TEL: (617) 542-6000 FAX: (617) 542-2241 APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after this Registration Statement becomes effective. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: |_| If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box: |X| If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. |X| 333-41782 If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. |_| If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. |_| -------------------- CALCULATION OF REGISTRATION FEE =========================== ============== ======================== ======================== ==================== TITLE OF EACH CLASS OF AMOUNT TO BE PROPOSED MAXIMUM PROPOSED MAXIMUM AMOUNT OF SECURITIES TO BE REGISTERED REGISTERED OFFERING PRICE PER SHARE AGGREGATE OFFERING PRICE REGISTRATION FEE (1) --------------------------- -------------- ------------------------ ------------------------ -------------------- Common Stock, $ .01 par value...................... 556,098 shares $12.50 $6,951,225 $1,662 =========================== ============== ======================== ======================== ==================== (1) 3,000,000 shares were previously registered on a Registration Statement on Form S-3 (Registration No. 333-41782), for which a filing fee of $13,662 was previously paid with such Registration Statement. The Registrant has instructed a bank to transmit a wire transfer to the Securities and Exchange Commission (the "Commission") of the requisite fee for this Registration Statement, the Registrant will not revoke such instruction, and it has sufficient funds in the relevant account to cover the amount of the registration fee. INCORPORATION OF CERTAIN INFORMATION BY REFERENCE This Registration Statement is being filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended. This Registration Statement relates to the public offering of Common Stock of Epix Medical, Inc. contemplated by a Registration Statement on Form S-3, Registration No. 333-41782 (the "Prior Registration Statement"), and is filed solely to increase the number of shares available for such offering by 556,098 shares. The contents of the Prior Registration Statement are hereby incorporated by reference into this Registration Statement. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form S-3 and has duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto duly authorized, in the Town of Cambridge, Massachusetts, on January 14, 2002. EPIX MEDICAL, INC. By: /s/ MICHAEL D. WEBB ----------------------------- Michael D. Webb Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities held on the dates indicated. SIGNATURES TITLE DATE /s/ MICHAEL D. WEBB Chief Executive Officer January 14, 2002 -------------------------------------- (Principal Executive Officer) Michael D. Webb * Vice President of Finance January 14, 2002 -------------------------------------- and Administration and Pamela E. Carey Chief Financial Officer (Principal Financial and Accounting Officer) * Chairman of the Board and January 14, 2002 -------------------------------------- Christopher F. O. Gabrieli Director * Director January 14, 2002 -------------------------------------- Stanley T. Crooke, M.D., Ph.D. * Director January 14, 2002 -------------------------------------- Randall B. Lauffer, Ph.D. Director -------------------------------------- Peter K. Wirth * By executing his name hereto, Michael D. Webb is signing this document on behalf of the persons indicated above pursuant to powers of attorney duly executed by such persons and filed with the Securities and Exchange Commission. By: /s/ MICHAEL D. WEBB ------------------------------ Michael D. Webb Attorney-in-Fact 3 EXHIBIT INDEX All exhibits filed with or incorporated by reference in the Registration Statement on Form S-3 (Registration No. 333-41782) are incorporated by reference into, and shall be deemed a part of, this Registration Statement, and the following additional exhibits are filed herewith: EXHIBIT NUMBER DESCRIPTION 5.1 - Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. with respect to the legality of securities being registered. 23.1 - Consent of Ernst & Young LLP. 23.2 - Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in Exhibit 5.1 to this Registration Statement on Form S-3).