Filed by Howtek, Inc. pursuant to Rule 425 of the
                        Securities Act of 1933 and also deemed filed pursuant to
                        Rule 14a-6 of the Securities Exchange Act of 1934.
                        Subject Company: Intelligent Systems Software Inc.
                        Commission file no:-333-86454

News Release

For further information contact:

Gregory Stepic                                           Connie Webster
Vice President and Chief Financial Officer               Corporate Secretary
Intelligent Systems Software, Inc.                       Howtek, Inc.
(561) 994-4404                                           (603) 882-5200

     Intelligent Systems Software Believes R2 Technology Patent Infringement
                             Lawsuit Without Merit

June 5, 2002 - Intelligent Systems Software, Inc. (ISSI) and Howtek, Inc.
(NASDAQ:HOWT) jointly announced today that R2 Technology, Inc. has filed a
lawsuit against ISSI alleging that ISSI's MammoReader(TM) system infringes on
certain R2 patents. The complaint was filed in United States District Court for
the District of Delaware. The complaint asks for a permanent injunction against
further infringement and unspecified damages.

W. Kip Speyer, ISSI's President and Chief Executive Officer, said: "Our patent
counsel has reviewed the R2 patents and has advised Intelligent Systems that the
patent infringement claims are without merit." Mr. Speyer said, "ISSI intends to
vigorously defend the lawsuit."

According to Mr. Speyer and W. Scott Parr, Howtek's Chief Executive Officer,
"the lawsuit is not expected to have an impact on the proposed merger of Howtek
and ISSI."

In February 2002, ISSI announced that it had entered into a definitive agreement
with Howtek, Inc. to merge ISSI into Howtek. The proposed merger is subject to
the satisfaction of several conditions, including stockholder approval.

About Intelligent Systems Software, Inc.

ISSI, based in Boca Raton, Florida, is a privately held company solely dedicated
to the development of products for medical image analysis. The MammoReader(TM)
is the first product to be introduced by ISSI. More information about ISSI can
be found at

About Howtek, Inc.

Howtek, based in Hudson, New Hampshire, designs, engineers, and manufactures
digital image scanners, film digitizers and related software for applications in
the medical imaging, women's health and photographic markets. More information
about Howtek can be found at


Howtek has filed a registration statement on Form S-4 with the Securities and
Exchange Commission relating to the proposed merger of Howtek and ISSI. A proxy
statement/prospectus relating to the proposed merger was included in the
registration statement and is being mailed to stockholders of Howtek and ISSI
who are entitled to vote on the merger. Security holders of Howtek and ISSI and
potential investors are invited to read the proxy statement/prospectus regarding
the proposed merger of Howtek and ISSI since it contains important information
regarding the proposed transaction. Security holders of Howtek and ISSI and
prospective investors may obtain a free copy of the proxy statement/prospectus
and Howtek's Form 10-K for the fiscal year ended December 31, 2001 and Form 10-Q
for the quarter ended March 31, 2002 which are being delivered to stockholders
who are voting on the proposed merger, free of charge from the Securities and
Exchange Commission's website at The proxy
statement/prospectus and such other documents may also be obtained from Howtek
free of charge by directing such requests to Howtek's Corporate Secretary at 21
Park Avenue, Hudson, NH 03051 or by calling Howtek's Corporate Secretary at
(603) 882-5200. Howtek and its officers and directors may be deemed to be
participants in the solicitation of proxies from stockholders of Howtek with
respect to the approval of the proposed merger. Information regarding such
officers and directors, including their direct or indirect interests in the
proposed merger arising from their securities holdings or otherwise, is set
forth in or incorporated into the proxy statement/prospectus.

Certain statements contained in this News Release constitute "forward-looking
statements" within the meaning of the Private Securities Litigation Reform Act
of 1995. Such forward-looking statements involve a number of known and unknown
risks, uncertainties and other factors which may cause the actual results,
performance or achievements to be materially different from any future results,
performance or achievements expressed or implied by such forward-looking
statements. Such factors include, but are not limited to, the risks of
uncertainty of litigation, the risks of uncertainty of stockholder and other
approvals necessary to consummate the proposed merger, the risk that Howtek's
and ISSI's businesses will not be successfully integrated if the merger is
consummated, the effect of costs and accounting charges relating to the merger,
and other economic, business, competitive and/or regulatory factors affecting
Howtek's and ISSI's businesses generally which are detailed in the proxy
statement/prospectus relating to the proposed merger and in Howtek's other
filings with the Securities and Exchange Commission. The words "believe,"
"demonstrate," "intend," "expect," "estimate," "anticipate," "likely" and
similar expressions identify forward-looking statements. Readers are cautioned
not to place undue reliance on those forward-looking statements, which speak
only as of the date the statement was made.

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