UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                       -----------------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of report (Date of earliest event reported): October 17, 2006
                                                         ----------------

                               CYTOGEN CORPORATION
               --------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)

           Delaware                     000-14879                 22-2322400
------------------------------   ------------------------    -------------------
 (State or Other Jurisdiction    (Commission File Number)     (I.R.S. Employer
       of Incorporation)                                     Identification No.)

650 College Road East, CN 5308, Suite 3100, Princeton, NJ            08540
----------------------------------------------------------      ----------------
        (Address of Principal Executive Offices)                   (Zip Code)


       Registrant's telephone number, including area code: (609) 750-8200


--------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)



     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     |_|  Written communications  pursuant to Rule 425 under the  Securities Act
(17 CFR 230.425)

     |_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_|  Pre-commencement  communications  pursuant to Rule 14d-2(b)  under the
Exchange Act (17 CFR 240.14d-2(b))

     |_|  Pre-commencement  communications  pursuant to Rule 13e-4(c)  under the
Exchange  Act  (17  CFR  240.13e-4(c))





ITEM 5.03  AMENDMENTS TO ARTICLES OF  INCORPORATION OR BY-LAWS; CHANGE IN FISCAL
           YEAR.

     On October  17,  2006,  the Board of  Directors  (the  "Board")  of Cytogen
Corporation (the "Company") resolved to immediately amend Article III, Section 6
of the  Company's  By-Laws to  decrease  the number of days  notice that must be
given to call a special  meeting of the Board from two days' notice to one days'
notice.  The  Company's  Amended and  Restated  By-Laws are  attached  hereto as
Exhibit 3.1 and incorporated herein by reference.  The foregoing  description of
the Amended and  Restated  By-Laws is  qualified in its entirety by reference to
such Exhibit.

ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS

(c)  Exhibits.

      Exhibit No.       Description
      -----------       -----------

         3.1            Amended and Restated By-Laws of Cytogen Corporation







                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                        CYTOGEN CORPORATION



                                        By:  /s/ Michael D. Becker
                                           -------------------------------------
                                           Michael D. Becker
                                           President and Chief Executive Officer

Dated: October 19, 2006







                                  EXHIBIT INDEX


      Exhibit No.       Description
      -----------       -----------

          3.1           Amended and Restated By-Laws of Cytogen Corporation