SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                    FORM 11-K

                                  ANNUAL REPORT
                           PURSUANT TO SECTION 15 (d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934


     (Mark One)
     [X]     ANNUAL REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES
             EXCHANGE ACT OF 1934


                   For the fiscal year ended December 31, 2002

                                       OR

     [ ]     TRANSITION REPORT PURSUANT TO SECTION 15 (d) OF THE
             SECURITIES EXCHANGE ACT OF 1934

           For the transition period from ____________ to ____________


                        Commission File Number 000-14879


            A.   Full  title  of the plan  and the  address  of the
                 plan,  if different  from that of the issuer named
                 below:


                         CYTOGEN RETIREMENT SAVINGS PLAN


            B.   Name of issuer of the securities  held pursuant to
                 the  plan  and  the   address  of  its   principal
                 executive office:

                               CYTOGEN CORPORATION
                          650 COLLEGE ROAD EAST CN-5308
                                   SUITE 3100
                            PRINCETON, NJ 08540-5308
                                  (609)750-8200






                         CYTOGEN RETIREMENT SAVINGS PLAN
                    INDEX TO FINANCIAL STATEMENT AND SCHEDULE

                                DECEMBER 31, 2002




                                                                        Page No.
                                                                        --------
Required Information......................................................  2

Independent Auditors' Report..............................................  3

Financial Statements:
  Statements of Net Assets Available for Plan Benefits
    As of December 31, 2002 and 2001......................................  4
  Statement of Changes in Net Assets Available for Plan Benefits
    For the Year Ended December 31, 2002..................................  5

Notes to Financial Statements.............................................  6

Supplemental Schedule:
  Schedule H, Line 4i - Schedule of Assets
    (Held at End of Year)
      As of December 31, 2002............................................. 11

Signature ................................................................ 12

Exhibit 23 - Independant Auditors' Consent................................ 13

Exhibit 99.1 Certification Pursuant to 18 U.S.C. Section 1350,
 As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002..... 14

Exhibit 99.2 Certification Pursuant to 18 U.S.C. Section 1350,
 As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002..... 15





                              REQUIRED INFORMATION




1.   Financial  Statements and Schedule of the Cytogen  Retirement  Savings Plan
     prepared in accordance  with the financial  reporting  requirements  of the
     Employee Retirement Income Security Act of 1974, as amended.


Exhibit 23.  Consent of KPMG, LLP.

Exhibit 99.1 Certification Pursuant to 18 U.S.C. Section 1350, As Adopted
             Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 99.2 Certification Pursuant to 18 U.S.C. Section 1350, As Adopted
             Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002












                                       2

                          Independent Auditors' Report



To the Plan Administrator of
Cytogen Retirement Savings Plan:


We have audited the  accompanying  statements  of net assets  available for plan
benefits of Cytogen  Retirement  Savings Plan (the Plan) as of December 31, 2002
and 2001, and the related  statement of changes in net assets available for plan
benefits for the year ended December 31, 2002.  These  financial  statements are
the responsibility of the Plan's management. Our responsibility is to express an
opinion on these financial statements based on our audits.

We conducted our audits in accordance with auditing standards generally accepted
in the  United  States of  America.  Those  standards  require  that we plan and
perform the audit to obtain  reasonable  assurance  about  whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis,  evidence  supporting  the amounts and  disclosures in the financial
statements.  An audit also includes assessing the accounting principles used and
significant  estimates  made by  management,  as well as evaluating  the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material respects, the net assets available for plan benefits of the Plan as
of December 31, 2002 and 2001, and the changes in net assets  available for plan
benefits of the Plan for the year ended  December 31, 2002, in  conformity  with
accounting principles generally accepted in the United States of America.

Our audit was  performed  for the  purpose  of  forming  an opinion on the basic
financial  statements taken as a whole.  The supplemental  schedule is presented
for the purpose of  additional  analysis and is not a required part of the basic
financial  statements,   but  is  supplementary   information  required  by  the
Department of Labor's Rules and Regulations  for Reporting and Disclosure  under
the Employee Retirement Income Security Act of 1974. This supplemental  schedule
has been subjected to the auditing  procedures applied in the audit of the basic
financial  statements  and, in our  opinion,  is fairly  stated in all  material
respects in relation to the basic financial statements taken as a whole.



                                             /s/ KPMG LLP
                                             ------------


Princeton, New Jersey
June 23, 2003





                                       3



                         CYTOGEN RETIREMENT SAVINGS PLAN

              Statements of Net Assets Available for Plan Benefits

                           December 31, 2002 and 2001





                                                     2002                   2001
                                                 ------------          ------------
                                                                 
Assets:
  Investments                                    $  3,699,908          $  5,266,813
  Participant contributions receivable                 13,044                16,990
  Employer contributions receivable                    18,612                47,510
  Interest receivable                                      61                     -
  Participant loans                                    34,066                     -
                                                 ------------          ------------

Net assets available for plan benefits           $  3,765,691          $  5,331,313
                                                 ============          ============


See accompanying notes to financial statements.


                                       4



                         CYTOGEN RETIREMENT SAVINGS PLAN

         Statement of Changes in Net Assets Available for Plan Benefits

                          Year Ended December 31, 2002






Net assets available for plan benefits, beginning of year           $ 5,331,313
Additions:
  Investment income:
    Dividend income from investments                                     89,599
    Interest income from loans                                              586
    Other income                                                            118
                                                                    -----------
                                                                         90,303
                                                                    -----------

  Contributions:
    Participants                                                        366,478
    Employer                                                             97,768
    Rollovers                                                               705
                                                                    -----------
                                                                        464,951
                                                                    -----------

           Total additions                                              555,254
                                                                    -----------

Deductions:
  Net depreciation in fair value of investments                       1,017,153
  Benefits paid to participants                                       1,099,850
  Plan expenses                                                           3,873
                                                                    -----------

           Total deductions                                           2,120,876
                                                                    -----------

           Net decrease                                              (1,565,622)
                                                                    -----------

Net assets available for plan benefits, end of year                 $ 3,765,691
                                                                    ===========


See accompanying notes to financial statements.



                                       5


                        CYTOGEN RETIREMENT SAVINGS PLAN

                         Notes to Financial Statements

                           December 31, 2002 and 2001



(1)    Description of the Plan

       (a)    Organization

              The  Cytogen  Retirement  Savings  Plan  (the  Plan) is a  defined
              contribution  plan for the employees of Cytogen  Corporation  (the
              Employer or the  Company)  that was  established  on December  15,
              1986.  The Plan is  governed  by the  provisions  of the  Employee
              Retirement Income Security Act of 1974 (ERISA), as amended, and is
              intended to comply with Sections 401(a) and 401(k) of the Internal
              Revenue Code.

              The  following  description  of the  Plan  provides  only  general
              information.  Participants should refer to the Plan document for a
              more complete description of the Plan's provisions.

       (b)    Eligibility

              Each employee  becomes  eligible to  participate in the Plan as of
              the date  when the  employee  attains  the age of 21 years and has
              completed six months of service.

       (c)    Administration

              The   Employer   designates  a  person  or  persons  to  serve  as
              administrator  under the Plan, who performs all such duties as are
              necessary  to  operate,  administer,  and  manage  the  Plan.  The
              expenses  necessary to administer the Plan are generally  borne by
              the Employer, including necessary professional assistance.

       (d)    Contributions

              Beginning January 1, 2002, each active  participant may enter into
              a written salary deferral agreement with the Employer in which the
              employee  may  elect to defer an amount of up to 75% of his or her
              compensation, subject to the maximum contribution level set by the
              Internal  Revenue  Code.  If the  participant  is age 50 or  older
              during the calendar year and makes the maximum  allowable  pre-tax
              contribution  to the Plan, the participant is entitled to make  an
              additional  "catch-up  contribution"  up to the maximum  allowable
              pre-tax contribution.  The Employer, at its discretion, may make a
              matching  contribution  in an  amount  up to 50%  of the  employee
              contribution, not to exceed limitations set forth by the Plan. The
              Employer   may  also   make  an  annual   Employer   discretionary
              contribution under the Plan in an amount that the Employer's Board
              of Directors shall determine by resolution. The allocation of this
              discretionary  contribution  shall be made in the proportion  that
              the  compensation  paid to each  participant  during the Plan year
              bears to the compensation paid to all such  participants,  subject
              to limitations set forth by the Plan. The Employer has the ability
              to make  discretionary or matching contribution in cash or Cytogen
              common stock.

              The Plan also permits the rollover of cash  transferred from other
              employee  benefit  plans which are  qualified  under the  Internal
              Revenue  Code.  Rollovers  of cash are  included  as part of asset
              additions in the statement of changes in net assets  available for
              plan benefits.  For the year ended December 31, 2002, rollovers of
              cash amounted to $705.


                                       6

                        CYTOGEN RETIREMENT SAVINGS PLAN

                         Notes to Financial Statements

                           December 31, 2002 and 2001


       (e)    Vesting and Forfeitures

              A participant's interest in the Employer matching or discretionary
              contribution  vests over four years of  service,  at which time it
              becomes 100% vested.  Vesting  credit shall be given for each year
              of service,  except plan years during which a participant  did not
              complete  at  least  1,000  hours  of  service.  If a  participant
              terminates  employment  and  is not  100%  vested,  the  nonvested
              portion of the participant's account shall be placed in a separate
              account and will become a forfeiture upon the date such terminated
              participant incurs a one-year break in service.  These forfeitures
              shall  be  used  by  the   Employer   to  reduce  the   Employer's
              contribution or to pay plan expenses. Forfeitures used during 2002
              were $47,639.

       (f)    Distributions/Benefits

              A participant who  attains the normal  retirement age shall have a
              vesting  percentage  of 100%.  If a  participant  retires from the
              active service of the  Employer on or after the normal  retirement
              date, then he or she is  entitled to receive a distribution of the
              entire  value of his or her  vested  participant  account,  or may
              elect to an annuity  distribution  as  permited  under the Plan. A
              participant  who  retires  from the  service  of the  Employer  on
              account of disability  shall have a vesting percentage of 100% and
              is  entitled  to receive a  distribution  of the entire  value of
              their participant account.

       (g)    Participant Loans

              All   participants   in   the  Plan  may  obtain,   under  certain
              conditions,  a loan  secured by the participant's account balance.
              The  amount of all  outstanding  loans to  a  participant  may not
              exceed  the  lesser of 50% of  the  participant's  vested  account
              balance or $50,000.  The loans  are made at a rate  equivalent  to
              rates charged by a professional lender  in similar  circumstances.
              Loans are repaid in no  more than five  years,  except if the loan
              is for the purchase of  the participant's  primary  residence,  in
              which case the repayment period may exceed five years.

       (h)    Investment Options

         Fund                                  Objective
-------------------------   ----------------------------------------------------
Oakmark International       Invests primarily in common stocks of non-U.S.
Fund (II)                   companies.

Merrill Lynch Fundamental   Invests primarily in a portfolio of common stocks of
Growth Fund,  Inc. (D)      U.S. companies with above-average rates of growth
                            earnings over the  long-term.

Merrill Lynch Global        Invests primarily in a portfolio of equity
SmallCap Fund, Inc. (D)     securities of small-cap issuers in foreign countries
                            and the U.S.

Federated Capital           Invests primarily in common stock of companies with
Appreciation Fund           medium and large market capitalizations  that offer
                            superior growth prospects or of companies whose
                            stock is undervalued.

Merrill Lynch Basic         Invests in undervalued, income producing equity
Value Fund (D)              securities.


                                       7

                        CYTOGEN RETIREMENT SAVINGS PLAN

                         Notes to Financial Statements

                           December 31, 2002 and 2001



         Fund                                  Objective
-------------------------   ----------------------------------------------------
Merrill Lynch Small Cap     Invests in  a diversified  portfolio  of securities,
Value Fund, Inc. (D)        primarily   common  stock, of   relatively  small
                            companies believed to have special  investment value
                            and emerging  growth companies regardless of size.

Alger MidCap Growth         Invests  primarily  in  the  equity  securities of
Portfolio (A)               companies having a market capitalization within  the
                            range of companies in the S&P MidCap 400 Index.

PIMCO Total Return          Invests  primarily  in a  diversified  portfolio  of
Fund (A)                    fixed income instruments of varying maturities.

Merrill Lynch U.S. High     Invests  primarily in a diversified  portfolio of
Yield Fund (D)              fixed income securities, such as corporate bonds and
                            notes, convertible securities  and  preferred  stock
                            that are rated in the lower rating categories of the
                            recognized rating agencies or unrated  securities
                            that  are  of  comparable quality.

Lord Abbett Mid Cap         Invests primarily in commons stocks and other equity
Value Fund Class (P)        securities of companies with good   prospects for
                            improvement in earnings  trends or asset values that
                            are not yet fully recognized in the investment
                            community.

Merrill Lynch U.S.          Invests in mortgage backed certificates and other
Government Mortgage         mortgage backed government securities.
Fund (D)

Seligman Communications &   Invests primarily in the securities of companies
Information Fund (A)        operating in the communications, information and
                            related industries.

Van Kampen Equity and       Invests primarily in income-producing equity
Income Fund (A)             securities and investment-grade debt securities.

Merrill Lynch Retirement    Invests  primarily  in  a  broadly  diversified
Preservation Trust          portfolio of Guaranteed Investment Contracts as well
                            as in obligations go U.S. government and U.S.
                            government agency securities and money market
                            securities.


       (i)    Termination

              As of a participant's  termination of employment,  he or she shall
              be entitled to receive a distribution  of his or her entire vested
              interest.  Such distribution shall be further subject to terms and
              conditions set forth by the Plan.

(2)    Summary of Significant Accounting Policies

       (a)    Basis of Accounting

              The Plan is subject to the  provisions of the Employee  Retirement
              Income Security Act of 1974, as amended (ERISA).  The accompanying
              financial  statements  have been  prepared on the accrual basis of

                                       8

                        CYTOGEN RETIREMENT SAVINGS PLAN

                         Notes to Financial Statements

                          December 31, 2002 and 2001


              accounting,  except for distributions  that are accounted for on a
              cash basis in accordance with the AICPA Audit and Accounting Guide
              entitled Audits of Employee Benefit Plans.  Investments are stated
              at market value.

       (b)    Use of Estimates

              The  preparation  of  financial   statements  in  conformity  with
              accounting  principles  generally  accepted  in the United  States
              requires  management to make estimates and assumptions that affect
              the financial  statements and the related  disclosures  during the
              reporting   period.   Actual   results  could  differ  from  those
              estimates.

       (c)    Valuation of Investments

              Investments  represent  units in a series of funds  managed by the
              investment  manager.  The  Plan's  investment  funds are stated at
              market  value,  as  determined  based  on  market  quotes  of  the
              underlying assets.

       (d)    Plan Expenses

              All administrative costs associated with the operation of the Plan
              are generally paid by the Employer in accordance with the terms of
              the Plan.

       (e)    Purchases and Sales of Securities

              Purchases  and sales of  securities  are  recorded on a trade date
              basis.



                                       9

                        CYTOGEN RETIREMENT SAVINGS PLAN

                         Notes to Financial Statements

                          December 31, 2002 and 2001


(3)    Investments

       The following table presents the current values of individual assets that
       represent 5% or more of the Plan's net assets available for plan benefits
       as of December 31, 2002 and 2001 as follows:




             Description?Issuer of Investment                 2002          2001
       --------------------------------------------      -----------    -----------

                                                                  
       Merrill Lynch Fundamentaal Growth Fund, Inc.      $   568,680    $         -
       Federated Capital Appreciation Fund                   594,925              -
       Merrill Lynch U.S. Government Mortgage Fund           472,823              -
       Merrill Lynch Retirement Preservation Trust         1,513,160              -
       MFS Emerging Growth Fund                                    -        433,869
       Massachusetts Investor Trust                                -        324,116
       Massachusetts Investor Growth Stock Fund                    -      1,096,579
       MFS Research Fund                                           -        384,914
       MFS Capital Opportunities Fund                              -        577,702
       MFS Government Securities Fund                              -        667,617
       MFS Global Equity Fund                                      -        349,929
       MFS Fixed Fund                                              -        877,372



(4)    Tax Status

       The trust  established  under the Plan is  qualified  under the  Internal
       Revenue Code as exempt from federal income taxes. The Plan has received a
       favorable  determination letter from the Internal Revenue Service but has
       not been updated for the most recent plan  amendment.  However,  the Plan
       Administrator  and the  Plan's  tax  counsel  believe  that  the  plan is
       currently  designed and being operated in compliance  with the applicable
       requirements of the Internal Revenue Code.  Therefore,  they believe that
       the Plan was  qualified  and the related  trust was  tax-exempt as of the
       financial statement date.

(5)    Plan Termination

       Although  it has not  expressed  any intent to do so, the Company has the
       right under the Plan to discontinue its  contributions  at anytime and to
       terminate the Plan,  subject to the provisions of ERISA.  In the event of
       termination,  distributions  shall be subject to the terms and conditions
       set forth by the Plan.

(6)    Distributions/Benefits Paid to Participants

       Distributions/benefits  paid  to  participants  are  generally  made on a
       monthly basis for those requests  processed in the previous month.  There
       were no distributions/benefits payable to the participants as of December
       31, 2002.


                                       10



                                                                      Schedule 1


                         CYTOGEN RETIREMENT SAVINGS PLAN

         Schedule H, Line 4i - Schedule of Assets (Held at End of Year)

                                December 31, 2002

                                                                       Market
                Description of investment                              value
-------------------------------------------------------------     --------------

  Oakmark International Fund (II)                                 $       1,673
  Merrill Lynch Fundamental Growth Fund, Inc. (D)                       568,680
  Merrill Lynch Global SmallCap Fund, Inc. (D)                          170,322
  Federated Capital Appreciation Fund                                   594,925
  Merrill Lynch Basic Value Fund (D)                                    131,062
  Merrill Lynch Small Cap Value Fund, Inc. (D)                              825
  Alger MidCap Growth Portfolio (A)                                      55,999
  PIMCO Total Return Fund (A)                                             2,478
  Merrill Lynch U.S. High Yield Fund (D)                                  9,955
  Lord Abbett Mid Cap Value Fund Class (P)                                  824
  Merrill Lynch U.S. Government Mortgage Fund (D)                       472,823
  Seligman Communications & Information Fund (A)                         13,984
  Van Kampen Equity and Income Fund (A)                                 126,698
  Merrill Lynch Retirement Preservation Trust                         1,513,160
* CYTOGEN Corporation Stock Fund                                         36,500
                                                                   -------------
         Total Investments                                         $   3,699,908
                                                                   =============

Participant Loans                                                  $      34,066
                                                                   =============

* Represents a party-in-interest.



                                       11


                                    SIGNATURE



                                    THE PLAN



Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the Plan
has duly caused this annual report to be signed on its behalf by the undersigned
hereunto duly authorized.

                                     CYTOGEN RETIREMENT SAVINGS PLAN
                                     By: Cytogen Corporation, Plan Administrator
Date:   June 26, 2003                By: /s/ Rita Auld
      ----------------------             ---------------------------------------
                                         Rita Auld
                                         Vice President, Human Resources and
                                         Administration






                                       12