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Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting of Stockholders To Be Held on June 12, 2019 for AVEO Pharmaceuticals, Inc.    This communication is not a form of voting and presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. To view the proxy statement, annual report, directions to the annual meeting and voting instructions, go to www.proxydocs.com/AVEO. To submit your proxy while visiting this site, you will need the 12 digit control number in the box below.   Under United States Securities and ExchangeCommission rules, proxy materials do not have to bedelivered in paper. Proxy materials can be distributedby making them available on the Internet. We havechosen to use these procedures for our 2019 AnnualMeeting and need YOUR participation.    If you want to receive a paper or e-mail copy of theproxy materials, you must request one. There is nocharge to you for requesting a copy. In order toreceive a paper package in time for our Annual Meeting, please make this request on or before June 2, 2019.     For a Convenient Way to VIEW Proxy Materials – and – VOTE Online go to: www.proxydocs.com/AVEO    Proxy Materials Available to View or Receive: Annual Report and Proxy Statement    Printed materials may be requested by one of the following methods:     TELEPHONE(866)648-8133 * If requesting material by e-mail, please send a blank email with the 12 digit control number (located below) in You must use the 12 digit control number  the subject line. No other requests, instructions or other located in the shaded gray box below. inquiries should be included with your e-mail requesting material.     AVEO Pharmaceuticals, Inc. Notice of Annual Meeting     Meeting Type: Annual Meeting For holders as of: April 15, 2019    Date: Wednesday, June 12, 2019 Time: 10:00 a.m. (Eastern Time) Donnelley Financial Solutions, 20 Custom House Street, Place: 7th Floor, Boston, MA 02110    The Board of Directors Recommends a Vote FOR each of the director nominees listed in proposal 1 and FOR proposal 2, 3,4, 5 and 6.    1. To elect five directors, each to serve for a one-year term expiring at the 2020 annual meeting of stockholders Nominees: (1) Michael P. Bailey (2) Kenneth M. Bate (3) Anthony B. Evnin, Ph.D. (4) Gregory T. Mayes (5) Robert C. Young, M.D. 2. To approve an advisory vote on executive compensation. 3. To approve the AVEO Pharmaceuticals, Inc. 2019 Equity Incentive Plan. 4. To approve an amendment to our Restated Certificate of Incorporation to increase the number of authorized shares of our common stock from250,000,000 to 500,000,000. 5. To approve an amendment to our Restated Certificate of Incorporation to effect a reverse stock split of our common stock, by a ratio of not less than1-for-5 and not more than 1-for-15, and a proportionate reduction in the number of authorized shares of common stock, such ratio and the implementation and timing of the reverse stock split to be determined in the discretion of our board of directors. 6. To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2019. Note: To conduct any other business properly brought before the Annual Meeting. INTERNET www.investorelections.com/AVEO    *E-MAIL paper@investorelections.com    Vote In-Person Instructions: While we encourage stockholders to vote by the means indicated above, a stockholder is entitled to vote in person at the Annual Meeting. If you wish to vote your shares at the Annual Meeting, please register with the Inspector of Elections at the desk marked “Stockholder Registration” at the entrance to receive a ballot. Proper photo ID is required. Ballots should be returned to the Inspector of Elections in order to be counted. Additionally, a stockholder who has submitted a proxy before the meeting may revoke that proxy in person at the Annual Meeting.