PAGE 1
000 B000000 09/30/2006
000 C000000 0001071899
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 Y
000 H000000 N
000 I000000 6.1
000 J000000 U
001 A000000 BLACKROCK MUNIHOLDINGS INSURED FUND II, INC.
001 B000000 811-9191
001 C000000 6092822800
002 A000000 P.O. BOX 9011
002 B000000 PRINCETON
002 C000000 NJ
002 D010000 08543
002 D020000 9011
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
014 A000001 MLPF&S AND OTHER ML BROKER/DEALER AFFILIATES
014 B000001 8-7221
014 A000002 BLACKROCK INVESTMENTS, INC.
014 B000002 8-048436
014 A000003 NORTHERN FUND DISTRIBUTORS, LLC
014 B000003 8-051242
014 A000004 PNC CAPITAL MARKETS, LLC
014 B000004 8-032493
014 A000005 J.J.B. HILLIARD W.L. LYONS, INC.
014 B000005 8-033133
014 A000006 PFPC DISTRIBUTORS, INC.
014 B000006 8-045467
014 A000007 MGI FUNDS DISTRIBUTORS, INC.
014 B000007 8-046960
014 A000008 ABN AMRO DISTRIBUTION SERVICES, INC.
014 B000008 8-052396
014 A000009 BLACKROCK DISTRIBUTORS, INC.
014 B000009 8-048775
PAGE 2
014 A000010 PERSIMMON SECURITIES, INC.
014 B000010 8-053071
014 A000011 PNC INVESTMENTS LLC
014 B000011 8-066195
014 A000012 STATE STREET RESEARCH INVEST SERVICES, INC.
014 B000012 8-035442
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02101
015 E010001 X
018 000000 Y
019 A000000 Y
019 B000000 177
019 C000000 BLACKROCKC
020 A000001 RBS GREENWICH CAPITAL
020 C000001 1
020 A000002 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
020 B000002 13-5674085
020 C000002 1
020 C000003 0
020 C000004 0
020 C000005 0
020 C000006 0
020 C000007 0
020 C000008 0
020 C000009 0
020 C000010 0
021 000000 2
022 A000001 MERRILL LYNCH INSTITUTIONAL TAX-EXEMPT FUND
022 B000001 22-2509978
022 C000001 120000
022 D000001 123100
022 A000002 J.P. MORGAN SECURITIES INC.
022 B000002 13-3224016
022 C000002 76521
022 D000002 74448
022 A000003 MURIEL SIEBERT & CO., INC.
022 C000003 25298
022 D000003 24124
022 A000004 CITIGROUP GLOBAL MARKETS, INC.
022 B000004 11-2418191
022 C000004 16788
022 D000004 23246
022 A000005 GOLDMAN, SACHS & CO.
022 B000005 13-5108880
022 C000005 16608
022 D000005 11389
022 A000006 MORGAN STANLEY
022 B000006 13-2655998
PAGE 3
022 C000006 16620
022 D000006 3796
022 A000007 UBS FINANCIAL SERVICES INC.
022 B000007 13-2638166
022 C000007 10532
022 D000007 7400
022 A000008 BANC OF AMERICA SECURITIES LLC
022 B000008 56-2058405
022 C000008 2017
022 D000008 13187
022 A000009 RBC DAIN RAUSCHER INC.
022 B000009 41-0212020
022 C000009 3344
022 D000009 9303
022 A000010 LEHMAN BROTHERS INC.
022 B000010 13-2518466
022 C000010 9075
022 D000010 2542
023 C000000 334756
023 D000000 328621
024 000000 N
055 A000000 Y
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 N
060 B000000 N
061 000000 0
062 A000000 Y
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.2
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 160.9
062 P000000 0.0
062 Q000000 0.0
062 R000000 1.5
063 A000000 0
063 B000000 16.4
064 A000000 Y
PAGE 4
064 B000000 N
070 A010000 Y
070 A020000 N
070 B010000 N
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 N
070 D020000 N
070 E010000 Y
070 E020000 Y
070 F010000 N
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 N
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 N
070 L010000 N
070 L020000 N
070 M010000 N
070 M020000 N
070 N010000 N
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 Y
070 Q010000 N
070 Q020000 N
070 R010000 N
070 R020000 N
071 A000000 197310
071 B000000 205154
071 C000000 508492
071 D000000 39
072 A000000 12
074 A000000 44
074 B000000 0
074 C000000 500
074 D000000 508941
074 E000000 0
074 F000000 0
074 G000000 0
074 H000000 0
074 I000000 4616
PAGE 5
074 J000000 55
074 K000000 0
074 L000000 7354
074 M000000 11
074 N000000 521521
074 O000000 0
074 P000000 197
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 524
074 S000000 204584
074 T000000 316216
074 U010000 22352
074 U020000 0
074 V010000 14.15
074 V020000 0.00
074 W000000 0.0000
074 X000000 81
074 Y000000 516635
075 A000000 0
075 B000000 516312
077 A000000 Y
077 B000000 Y
077 C000000 Y
077 K000000 Y
077 O000000 Y
077 Q010000 Y
078 000000 N
080 A000000 ICI MUTUAL INSURANCE CO.
080 C000000 900
081 A000000 Y
081 B000000 131
082 A000000 N
082 B000000 0
083 A000000 N
083 B000000 0
084 A000000 N
084 B000000 0
085 A000000 Y
085 B000000 N
086 A010000 0
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
PAGE 6
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 09254C107
087 A030000 MUE
087 B010000 PREFERRED STOCK
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 Y
SIGNATURE DONALD C. BURKE
TITLE TREASURER