UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                    FORM 6-K

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                            REPORT OF FOREIGN ISSUER

                       Pursuant to Rule 13a-16 or 15d-16
                     of the Securities Exchange Act of 1934


                                December 5, 2008


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                                NOVO NORDISK A/S
             (Exact name of Registrant as specified in its charter)


                                    NOVO ALLE
                               DK-2880, BAGSVAERD
                                     DENMARK
                    (Address of principal executive offices)

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Indicate by check mark whether the registrant files or will file annual reports
under cover of Form 20-F or Form 40-F

                       Form 20-F [X]     Form 40-F [ ]


Indicate by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

                             Yes [ ]     No [X]


If "Yes" is marked, indicate below the file number assigned to the registrant in
connection with Rule 12g-32(b):82-_____________________



DIRECTOR/PDMR SHAREHOLDING

TRADING IN NOVO NORDISK SHARES BY BOARD MEMBERS, EXECUTIVES AND ASSOCIATED
PERSONS AS REPORTED TO NOVO NORDISK ON 1 DECEMBER 2008

In accordance with Section 28a of the Danish Securities Trading Act, Novo
Nordisk is required on a daily basis to publish trading in Novo Nordisk shares
by the company's board members, executives and their associated persons as
reported by those persons to Novo Nordisk.

Please find below a statement of such trading in shares issued by Novo Nordisk.

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NAME                                 LARS REBIEN S0RENSEN
                                     JESPER BRANDGAARD
                                     LISE KINGO
                                     KARE SCHULTZ
                                     MADS KROGSGAARD THOMSEN
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REASON FOR REPORTING                 MEMBERS OF EXECUTIVE MANAGEMENT
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FINANCIAL INSTRUMENT AND ID CODE     NOVO NORDISK B DK006010261
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TYPE OF TRANSACTION                  PURCHASE OF EMPLOYEE SHARES ACCORDING TO
                                     THE DANISH EMPLOYEE SHARE PROGRAMME
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DATE OF TRANSACTION                  28 NOVEMBER 2008
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PLACE OF TRANSACTION                 NASDAQ OMX COPENHAGEN
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VOLUME OF TRANSACTION                100 SHARES
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TOTAL VALUE OF TRANSACTION           DKK 15,000
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NAME                                 JOHNNY HENRIKSEN
                                     ANNE MARIE KVERNELAND
                                     S0REN THUESEN PEDERSEN
                                     STIG STR0BAEK
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REASON FOR REPORTING                 MEMBERS OF THE BOARD OF DIRECTORS
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FINANCIAL INSTRUMENT AND ID CODE     NOVO NORDISK B DK006010261
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TYPE OF TRANSACTION                  PURCHASE OF EMPLOYEE SHARES ACCORDING TO
                                     THE DANISH EMPLOYEE SHARE PROGRAMME
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DATE OF TRANSACTION                  28 NOVEMBER 2008
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PLACE OF TRANSACTION                 NASDAQ OMX COPENHAGEN
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VOLUME OF TRANSACTION                100 SHARES
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TOTAL VALUE OF TRANSACTION           DKK 15,000
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DEFINITIONS AND BACKGROUND INFORMATION:

PUBLICATION
Publication shall take place the day after Novo Nordisk receives sufficient
information on the trading. Publication is only required when the total amount
of transactions of a specific board member/executive and his/her associated
persons in any one calendar year has reached 5,000 euros.

WHO ARE BOARD MEMBERS, EXECUTIVES AND ASSOCIATED PERSONS?
Board members and executives are members of the Board of Directors and Executive
Management, respectively, of Novo Nordisk A/S. Associated persons are defined as
the following persons associated to a board member/executive: 1) spouse or
cohabitant, 2) children under the age of 18 years, 3) relatives defined as
brothers, sisters, parents, grandparents etc, children, grandchildren etc who
have shared the same household with a board member/executive for at least one
year, and 4) any legal person, including a company, a foundation or a
partnership, which is controlled directly or indirectly by a board
member/executive and/or a person mentioned in 1)-3), or to which a board
member/executive and/or a person mentioned in 1)-3) has managerial
responsibilities or economic interests substantially equivalent to the legal
person.

WHAT IS TRADING/TRANSACTION?
Trading is any kind of transaction, including shares purchased or otherwise
acquired, shares sold or otherwise disposed, gifts, mortgages and grants and
exercise of options, but not heritage.

WHAT IS FINANCIAL INSTRUMENT AND ID CODE?
Financial instrument includes shares listed on the NASDAQ OMX Copenhagen and
London Stock Exchange as well as ADRs listed on New York Stock Exchange, except
for ADRs held in 401(k) retirement plan by US-based employees. The ID code is
the code (ISIN DK006010261) of the Novo Nordisk share on the NASDAQ OMX
Copenhagen, the code (NVOB) on London Stock Exchange or the code (NVO) on New
York Stock Exchange.

WHAT IS DATE AND PLACE OF TRANSACTION?
Date of transaction is the actual transaction date. The place of transaction is
the actual place of transaction, ie NASDAQ OMX Copenhagen, London Stock Exchange
or New York Stock Exchange.

WHAT IS VOLUME AND VALUE OF TRANSACTION?
The volume of transaction is the number of shares (of DKK 1 nominal value) or
other financial instruments traded. The transaction value is the number of
shares traded multiplied by the transaction price. The exchange rate of the
Danish Central Bank (Nationalbanken) on the date of transaction is used for
calculating the transaction value in DKK in case of shares traded on London
Stock Exchange and ADRs listed on New York Stock Exchange.

Novo Nordisk is a healthcare company and a world leader in diabetes care. In
addition, Novo Nordisk has a leading position within areas such as haemostasis
management, growth hormone therapy and hormone replacement therapy. Novo Nordisk
manufactures and markets pharmaceutical products and services that make a
significant difference to patients, the medical profession and society. With
headquarters in Denmark, Novo Nordisk employs approximately 26,550 employees in
80 countries, and markets its products in 179 countries. Novo Nordisk's B shares
are listed on the stock exchanges in Copenhagen and London. Its ADRs are listed
on the New York Stock Exchange under the symbol 'NVO'. For more information,
visit novonordisk.com.

For further information please contact:

Media:                              Investors:

Outside North America:
Elin K Hansen                       Mads Veggerby Lausten
Tel: (+45) 4442 3450                Tel: (+45) 4443 7919
E-mail: ekh@novonordisk.com         E-mail: mlau@novonordisk.com

                                    Hans Rommer
                                    Tel: (+45) 4442 4765
                                    E-mail: hrmm@novonordisk.com

In North America:
Sean Clements                       Kasper Roseeuw Poulsen
Tel: (+1) 609 514 8316              Tel: (+45) 4442 4471
E-mail: secl@novonordisk.com        E-mail: krop@novonordisk.com

COMPANY ANNOUNCEMENT NO 79 / 2008



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf of the
undersigned, thereunto duly authorized.

Date: December 5, 2008                         NOVO NORDISK A/S
                             ---------------------------------------------------
                                            Lars Rebien Sorensen,
                                     President and Chief Executive Officer