As filed with the Securities and Exchange Commission on March 25, 2010
                                                     Registration No. 333-161701
________________________________________________________________________________

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                         POST EFFECTIVE AMENDMENT NO. 1
                                       TO
                      REGISTRATION STATTEMENT ON FORM S-4

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                               PURESPECTRUM, INC.
             (Exact name of Registrant as specified in its charter)

                 Delaware                              41-2233302
     (State or other jurisdiction of               (I.R.S. Employee
     incorporation or organization)              Identification Number)

                               340 Eisenhower Dr.
                              Bldg. 600, Suite 610
                            Savannah, Georgia 31406
                                 (912) 961-4980
              (Address, Including Zip Code, and Telephone Number,
       Including Area Code, of Registrant's Principal Executive Offices)
                          ___________________________

                     Delaware Corporation Organizers, Inc.
                      1201 North Market Street, 18th Floor
                           Wilmington, Delaware 19801
                                 (302) 658-9200
           (Name, Address, Including Zip Code, and Telephone Number,
                   Including Area Code, of Agent for Service)
                          ___________________________

                                   Copies to:

       Daniel D. Dinur, Esq.          and        David Michael Conner, Esq.
       Dinur and DeLuca, LLP                     Bouhan Williams & Levy, LLP
       One Lakeside Commons                      The Armstrong House
       990 Hammond Drive, Suite 760              477 Bull Street
       Atlanta, Georgia 30328                    Savannah, Georgia 31402
       (770) 395-3170                            (912) 236-2491

Approximate date of commencement of proposed sale to the public: Not applicable.

If  the only securities being registered on this form are being offered pursuant
to  dividend or interest reinvestment plans, please check the following box. [ ]

If  any  of  the securities being registered on this Form are to be offered on a
delayed  or  continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment  plans,  check  the  following  box.  [ ]


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If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number  of  the earlier effective
registration  statement  for  the  same  offering.  [ ]

If  this  Form is a post-effective amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box  and  list  the Securities Act
registration  statement  number  of the earlier effective registration statement
for  the  same  offering.  [ ]

If this Form is a registration statement pursuant to General Instruction I.D. or
a  post-effective amendment thereto that shall become effective upon filing with
the  Securities  and  Exchange  Commission  pursuant  to  Rule  462(e) under the
Securities  Act,  check  the  following  box.  [ ]

If  this  Form  is  a post-effective amendment to a registration statement filed
pursuant  to General Instruction I.D. filed to register additional securities or
additional  classes  of  securities pursuant to Rule 413(b) under the Securities
Act,  check  the  following  box.  [ ]

Indicate  by  check mark whether the registrant is a large accelerated filer, an
accelerated  filer, a non-accelerated filer, or a smaller reporting company. See
definition  of  "large  accelerated  filer,"  "accelerated  filer"  and "smaller
reporting  company"  in  Rule  12b-2  of  the  Exchange  Act.

Large Accelerated Filer [ ]                      Accelerated Filer [ ]

Non-Accelerated Filer [ ]                        Smaller reporting company [X]

(Do not check if a smaller reporting company)

                EXPLANATORY NOTE - DEREGISTRATION OF SECURITIES

This  Post-Effective  Amendment relates to Registration Statement No. 333-161701
to  Form  S-4  and  is being filed to deregister any securities of PureSpectrum,
Inc.,  a  Delaware  corporation,  f/k/a  International  Medical  Staffing,  Inc.
("PSRU"),  which  were  not  issued  in  the  exchange  pursuant  to the C-Reorg
transaction described in the Registration Statement and which was consummated on
November  3,  2009.  These  securities  are  as  follows:

     -    1,137,910  shares  of  common  stock,  $0.0001  par value, issuable to
          the  shareholders of PureSpectrum, Inc., a Nevada corporation ("PSPM")
          in  exchange  for  the shares of PSPM common stock held by them on the
          record  date,who  did  not  tender  those  shares  in  the  exchange;

     -    1,449,298  warrants  to  purchase  common  stock  registered  in  the
          Registration  Statement  which  have  expired  as  of  March 15, 2010,
          without  having  been  exercised  (the  "Expired  Warrants");  and

     -    1,449,298  shares  of  common  stock  underlying the Expired Warrants.

As  of  March  15, 2010, after the deadline for the completion of the exchanges,
(a)  all  of the remaining 194,967,438 shares of PSRU common stock registered in
the  Registration Statement were issued to former PSPM shareholders, and (b) all
of  the  remaining  43,956,173  unexpired  warrants  and  shares of common stock
underlying  such  warrants  retain  their  registered  status.

Pursuant  to the undertakings contained in Registration Statement No. 333-161701
to  remove  from  registration,  by  means  of  a  Post-Effective Amendment, any
securities  which  remain  unsold  at  the  termination of the offering, PSRU is
filing this Post-Effective Amendment to Registration Statement No. 333-161701 to
Form  S-4  to  deregister  the  above  unsold  securities.


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                                   SIGNATURES

Pursuant  to  the  requirements  of  the  Securities Act of 1933, the Registrant
certifies  that  it  has  reasonable grounds to believe that it meets all of the
requirements  for filing this Post-Effective Amendment No. 1 to Form S-4 and has
duly  caused this Post-Effective Amendment No. 1 to Form S-4 to be signed on its
behalf  by  the undersigned, thereunto duly authorized, in the City of Savannah,
State  of  Georgia,  on  March  25,  2010.

                                         Pure Spectrum, Inc.
                                         (Registrant)

                                         By: /S/ Lee L. Vanatta
                                             ------------------
                                         Name:   Lee L. Vanatta
                                         Title:  President, Principal Executive
                                                 Officer and Director

Pursuant  to the requirements of the Securities Act of 1933, this Post-Effective
Amendment  No.  1  to  Form  S-4 has been signed by the following persons in the
capacities  and  on  the  dates  indicated.

Signature                      Title                             Date
---------                      -----                             ----

/S/ Lee L. Vanatta             President and Director            March 24, 2010
------------------             [Principal Executive Officer]
Lee L. Vanatta

/S/ William R. Norton          Executive Vice President,         March 24, 2010
---------------------          Secretary and Director
William R. Norton

/S/ Susan W. Norton            Vice President of Administration  March 24, 2010
-------------------            and Acting Chief Financial
Susan W. Norton                Officer [Principal Financial and
                               Accounting Officer]

/S/ David Michael Conner       Director                          March 24, 2010
------------------------
David Michael Conner

/S/ Bill G. Garlan             Director                          March 24, 2010
------------------
Bill G. Garlan

/S/ Robert E. James, II        Director                          March 24, 2010
-----------------------
Robert E. James, II


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