Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
FHM IV LP
  2. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
601 UNION STREET, SUITE 3200
3. Date of Earliest Transaction (Month/Day/Year)
03/06/2008
(Street)

SEATTLE, WA 98101
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/06/2008   P   192 A $ 9.9 893,210 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   500 A $ 9.92 893,710 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   1,100 A $ 9.93 894,810 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   800 A $ 9.935 895,610 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   300 A $ 9.94 895,910 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   192 A $ 9.95 896,102 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   1,000 A $ 9.955 897,102 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   993 A $ 9.96 898,095 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   600 A $ 9.965 898,695 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   800 A $ 9.9675 899,495 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   400 A $ 9.97 899,895 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   500 A $ 9.9725 900,395 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   501 A $ 9.9775 900,896 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   2,100 A $ 9.98 902,996 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   1,300 A $ 9.985 904,296 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   400 A $ 9.99 904,696 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   1,100 A $ 9.995 905,796 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   800 A $ 9.9975 906,596 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   868 A $ 10 907,464 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   300 A $ 10.01 907,764 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   37 A $ 10.07 907,801 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   5,263 A $ 10.08 913,064 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   200 A $ 10.12 913,264 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   1,800 A $ 10.14 915,064 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/06/2008   P   100 A $ 10.18 915,164 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/10/2008   P   200 A $ 9.98 915,364 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/10/2008   P   100 A $ 10.04 915,464 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/10/2008   P   100 A $ 10.07 915,564 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/10/2008   P   200 A $ 10.0775 915,764 I By Frazier Healthcare V, LP (1) (2)
Common Stock 03/10/2008   P   160 A $ 10.18 915,924 I By Frazier Healthcare V, LP (1) (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
FHM IV LP
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    
Frazier Healthcare V, LP
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    
FHM V, LP
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    
FHM V, LLC
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    
FRAZIER HEALTHCARE IV LP
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    
FRAZIER AFFILIATES IV LP
601 UNION STREET, SUITE 3200
SEATTLE, WA 98101
    X    

Signatures

 FHM IV, LP, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

 Frazier Healthcare V, LP, By: FHM V, LP, its General Partner, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

 FHM V, LP, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

 FHM V, LLC, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

 Frazier Healthcare IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

 Frazier Affiliates IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer   03/10/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The securities are owned directly by Frazier Healthcare V, LP. FHM V, LP, a joint filer, serves as the general partner of Frazier Healthcare V, LP and FHM V, LLC, serves as the general partner of FHM V, LP. FHM V, LP and FHM V, LLC disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.
(2) There is no direct relationship among or between FHM V, LLC, FHM V, L.P. and Frazier Healthcare V, L.P., on the one hand, and FHM IV, LP, Frazier Healthcare IV, LP and Frazier Affiliates IV, LP, on the other. Beneficial ownership of Issuer shares as described herein and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose.
 
Remarks:
Exhibit 99.1 - Joint Filer Information

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