UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                (Amendment No.1)*


                    BIODELIVERY SCIENCES INTERNATIONAL, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                    Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    09060J106
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2006
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
13G is filed:

      |_|   Rule 13d-1(b)
      |X|   Rule 13d-1(c)
      |_|   Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


--------------------------------------------------------------------------------
CUSIP No. 09060J106
--------------------------------------------------------------------------------
1     NAME OF REPORTING PERSON: Laurus Master Fund, Ltd.

      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: 98-0337673
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Cayman Islands
--------------------------------------------------------------------------------
NUMBER OF         5     SOLE VOTING POWER:
SHARES
BENEFICIALLY            0 shares of Common Stock.*
OWNED BY          --------------------------------------------------------------
EACH              6     SHARED VOTING POWER:
REPORTING
PERSON                  1,392,420 shares of Common Stock.*
                  --------------------------------------------------------------
                  7     SOLE DISPOSITIVE POWER:

                        0 shares of Common Stock.*
                  --------------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER:

                        1,392,420 shares of Common Stock.*
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,392,420 shares of Common Stock.
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                             |X|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

      9.99%*
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON

      CO
--------------------------------------------------------------------------------

------------
      * Based on  13,938,146  shares of the common  stock,  par value $0.001 per
share (the "Shares") of  BioDelivery  Sciences  International,  Inc., a Delaware
corporation  (the  "Company")  outstanding,  as  represented  in  the  Company's
Quarterly  Report on Form 10-QSB for the period ended  September 30, 2006. As of
December 31, 2006, Laurus Master Fund, Ltd. (the "Fund") held (i) a common stock
purchase warrant (the "June Warrant #1") to acquire 22,500 Shares at an exercise
price of $0.001 per Share, subject to certain  adjustments,  (ii) a common stock
purchase  warrant (the "June Warrant #2") to acquire 7,500 Shares at an exercise
price of $0.001 per Share, subject to certain adjustments,  (iii) a common stock
purchase  warrant  (the  "January  Warrant #1") to acquire  39,574  Shares at an
exercise  price of $0.001 per Share,  subject  to  certain  adjustments,  (iv) a
common stock  purchase  warrant  (the  "January  Warrant #2") to acquire  29,700
Shares at an exercise price of $0.001 per Share, subject to certain adjustments;
(v) a common stock purchase warrant (the "February  Warrant") to acquire 350,000
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vi) a common  stock  purchase  warrant (the "May  Warrant") to acquire  483,871
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vii) a common stock purchase  warrant (the "July Warrant #1") to acquire 47,113
Shares at an exercise price of $3.00 per Share,  subject to certain adjustments;
(viii) a common stock purchase  warrant (the "July Warrant #2" and together with
the June  Warrant #1, the June  Warrant #2, the January  Warrant #1, the January
Warrant #2, the February  Warrant,  the May Warrant and the July Warrant #1, the
"Early  Warrants") to acquire 62,887  Shares,  at an exercise price of $3.00 per
Share, subject to certain adjustments, (ix) a common stock purchase Warrant (the
"December  Warrant #1") to acquire 943,305 Shares, at an exercise price of $3.05
per Share, subject to certain  adjustments,  (x) a common stock purchase warrant
(the  "December  Warrant  #2" and  together  with the  December  Warrant #1, the
"December  Warrants") to acquire 556,695  Shares,  at an exercise price of $3.05
per Share, subject to certain  adjustments,  (xi) a Convertible Term Note in the
aggregate principal amount of $2,500,000,  which is convertible into Shares at a
conversion rate of $2.45 per Share,  subject to certain adjustments ("Note #1");
(xii) a Convertible  Term Note in the aggregate  principal amount of $2,500,000,
which is  convertible  into  Shares at a  conversion  rate of $2.45  per  Share,
subject  to certain  adjustments  ("Note  #2",  and  together  with Note #1, the
"Notes");  and (xiii) 19,403 Shares. The Early Warrants and the Notes contain an
issuance limitation prohibiting the Fund from exercising those securities to the
extent that such exercise  would result in  beneficial  ownership by the Fund of
more than 4.99% of the Shares then issued and  outstanding  (the "4.99% Issuance
Limitation").  The December Warrants contain an issuance limitation  prohibiting
the Fund from exercising those securities to the extent that such exercise would
result in beneficial ownership by the Fund of more than 9.99% of the Shares then
issued and outstanding  (the "9.99%  Issuance  Limitation" and together with the
4.99% Issuance Limitation, the "Issuance Limitations"). The Issuance Limitations
may be waived by the Fund upon at least 75 days prior notice to the Company and,
other than in the case of the July Warrant #1, the July Warrant #2, the December
Warrant #1 and the December Warrant #2, shall also automatically become null and
void upon the occurrence  and/or  continuance of an Event of Default (as defined
in and pursuant to the terms of the applicable  instrument).  In the case of the
July Warrant #1, the July  Warrant #2, the December  Warrant #1 and the December
Warrant #2, the Issuance  Limitations shall also become  automatically  null and
void following notice to the Issuer of the occurrence  and/or  continuance of an
Event of Default  (as  defined in and  pursuant  to the terms of the  applicable
instrument).  The Fund is managed by Laurus Capital Management, LLC. Eugene Grin
and David Grin, through other entities, are the controlling principals of Laurus
Capital  Management,  LLC and share sole  voting and  investment  power over the
securities owned by the Fund reported in this Schedule 13G, as amended.


--------------------------------------------------------------------------------
CUSIP No. 09060J106
--------------------------------------------------------------------------------
1     NAME OF REPORTING PERSON: Laurus Capital Management, LLC

      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: 13-4150669
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
NUMBER OF         5     SOLE VOTING POWER:
SHARES
BENEFICIALLY            0 shares of Common Stock.*
OWNED BY          --------------------------------------------------------------
EACH              6     SHARED VOTING POWER:
REPORTING
PERSON                  1,392,420 shares of Common Stock.*
                  --------------------------------------------------------------
                  7     SOLE DISPOSITIVE POWER:

                        0 shares of Common Stock.*
                  --------------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER:

                        1,392,420 shares of Common Stock.*
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,392,420 shares of Common Stock.
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                             |X|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

      9.99%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON

      OO
--------------------------------------------------------------------------------


------------
      * Based on  13,938,146  shares of the common  stock,  par value $0.001 per
share (the "Shares") of  BioDelivery  Sciences  International,  Inc., a Delaware
corporation  (the  "Company")  outstanding,  as  represented  in  the  Company's
Quarterly  Report on Form 10-QSB for the period ended  September 30, 2006. As of
December 31, 2006, Laurus Master Fund, Ltd. (the "Fund") held (i) a common stock
purchase warrant (the "June Warrant #1") to acquire 22,500 Shares at an exercise
price of $0.001 per Share, subject to certain  adjustments,  (ii) a common stock
purchase  warrant (the "June Warrant #2") to acquire 7,500 Shares at an exercise
price of $0.001 per Share, subject to certain adjustments,  (iii) a common stock
purchase  warrant  (the  "January  Warrant #1") to acquire  39,574  Shares at an
exercise  price of $0.001 per Share,  subject  to  certain  adjustments,  (iv) a
common stock  purchase  warrant  (the  "January  Warrant #2") to acquire  29,700
Shares at an exercise price of $0.001 per Share, subject to certain adjustments;
(v) a common stock purchase warrant (the "February  Warrant") to acquire 350,000
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vi) a common  stock  purchase  warrant (the "May  Warrant") to acquire  483,871
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vii) a common stock purchase  warrant (the "July Warrant #1") to acquire 47,113
Shares at an exercise price of $3.00 per Share,  subject to certain adjustments;
(viii) a common stock purchase  warrant (the "July Warrant #2" and together with
the June  Warrant #1, the June  Warrant #2, the January  Warrant #1, the January
Warrant #2, the February  Warrant,  the May Warrant and the July Warrant #1, the
"Early  Warrants") to acquire 62,887  Shares,  at an exercise price of $3.00 per
Share, subject to certain adjustments, (ix) a common stock purchase Warrant (the
"December  Warrant #1") to acquire 943,305 Shares, at an exercise price of $3.05
per Share, subject to certain  adjustments,  (x) a common stock purchase warrant
(the  "December  Warrant  #2" and  together  with the  December  Warrant #1, the
"December  Warrants") to acquire 556,695  Shares,  at an exercise price of $3.05
per Share, subject to certain  adjustments,  (xi) a Convertible Term Note in the
aggregate principal amount of $2,500,000,  which is convertible into Shares at a
conversion rate of $2.45 per Share,  subject to certain adjustments ("Note #1");
(xii) a Convertible  Term Note in the aggregate  principal amount of $2,500,000,
which is  convertible  into  Shares at a  conversion  rate of $2.45  per  Share,
subject  to certain  adjustments  ("Note  #2",  and  together  with Note #1, the
"Notes");  and (xiii) 19,403 Shares. The Early Warrants and the Notes contain an
issuance limitation prohibiting the Fund from exercising those securities to the
extent that such exercise  would result in  beneficial  ownership by the Fund of
more than 4.99% of the Shares then issued and  outstanding  (the "4.99% Issuance
Limitation").  The December Warrants contain an issuance limitation  prohibiting
the Fund from exercising those securities to the extent that such exercise would
result in beneficial ownership by the Fund of more than 9.99% of the Shares then
issued and outstanding  (the "9.99%  Issuance  Limitation" and together with the
4.99% Issuance Limitation, the "Issuance Limitations"). The Issuance Limitations
may be waived by the Fund upon at least 75 days prior notice to the Company and,
other than in the case of the July Warrant #1, the July Warrant #2, the December
Warrant #1 and the December Warrant #2, shall also automatically become null and
void upon the occurrence  and/or  continuance of an Event of Default (as defined
in and pursuant to the terms of the applicable  instrument).  In the case of the
July Warrant #1, the July  Warrant #2, the December  Warrant #1 and the December
Warrant #2, the Issuance  Limitations shall also become  automatically  null and
void following notice to the Issuer of the occurrence  and/or  continuance of an
Event of Default  (as  defined in and  pursuant  to the terms of the  applicable
instrument).  The Fund is managed by Laurus Capital Management, LLC. Eugene Grin
and David Grin, through other entities, are the controlling principals of Laurus
Capital  Management,  LLC and share sole  voting and  investment  power over the
securities owned by the Fund reported in this Schedule 13G, as amended.


--------------------------------------------------------------------------------
CUSIP No. 09060J106
--------------------------------------------------------------------------------
1     NAME OF REPORTING PERSON:

      David Grin
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Israel
--------------------------------------------------------------------------------
NUMBER OF         5     SOLE VOTING POWER:
SHARES
BENEFICIALLY            0 shares of Common Stock.*
OWNED BY          --------------------------------------------------------------
EACH              6     SHARED VOTING POWER:
REPORTING
PERSON                  1,392,420 shares of Common Stock.*
                  --------------------------------------------------------------
                  7     SOLE DISPOSITIVE POWER:

                        0 shares of Common Stock.*
                  --------------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER:

                        1,392,420 shares of Common Stock.*
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,392,420 shares of Common Stock.
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                             |X|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

      9.99%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON

      IN
--------------------------------------------------------------------------------


------------
      * Based on  13,938,146  shares of the common  stock,  par value $0.001 per
share (the "Shares") of  BioDelivery  Sciences  International,  Inc., a Delaware
corporation  (the  "Company")  outstanding,  as  represented  in  the  Company's
Quarterly  Report on Form 10-QSB for the period ended  September 30, 2006. As of
December 31, 2006, Laurus Master Fund, Ltd. (the "Fund") held (i) a common stock
purchase warrant (the "June Warrant #1") to acquire 22,500 Shares at an exercise
price of $0.001 per Share, subject to certain  adjustments,  (ii) a common stock
purchase  warrant (the "June Warrant #2") to acquire 7,500 Shares at an exercise
price of $0.001 per Share, subject to certain adjustments,  (iii) a common stock
purchase  warrant  (the  "January  Warrant #1") to acquire  39,574  Shares at an
exercise  price of $0.001 per Share,  subject  to  certain  adjustments,  (iv) a
common stock  purchase  warrant  (the  "January  Warrant #2") to acquire  29,700
Shares at an exercise price of $0.001 per Share, subject to certain adjustments;
(v) a common stock purchase warrant (the "February  Warrant") to acquire 350,000
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vi) a common  stock  purchase  warrant (the "May  Warrant") to acquire  483,871
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vii) a common stock purchase  warrant (the "July Warrant #1") to acquire 47,113
Shares at an exercise price of $3.00 per Share,  subject to certain adjustments;
(viii) a common stock purchase  warrant (the "July Warrant #2" and together with
the June  Warrant #1, the June  Warrant #2, the January  Warrant #1, the January
Warrant #2, the February  Warrant,  the May Warrant and the July Warrant #1, the
"Early  Warrants") to acquire 62,887  Shares,  at an exercise price of $3.00 per
Share, subject to certain adjustments, (ix) a common stock purchase Warrant (the
"December  Warrant #1") to acquire 943,305 Shares, at an exercise price of $3.05
per Share, subject to certain  adjustments,  (x) a common stock purchase warrant
(the  "December  Warrant  #2" and  together  with the  December  Warrant #1, the
"December  Warrants") to acquire 556,695  Shares,  at an exercise price of $3.05
per Share, subject to certain  adjustments,  (xi) a Convertible Term Note in the
aggregate principal amount of $2,500,000,  which is convertible into Shares at a
conversion rate of $2.45 per Share,  subject to certain adjustments ("Note #1");
(xii) a Convertible  Term Note in the aggregate  principal amount of $2,500,000,
which is  convertible  into  Shares at a  conversion  rate of $2.45  per  Share,
subject  to certain  adjustments  ("Note  #2",  and  together  with Note #1, the
"Notes");  and (xiii) 19,403 Shares. The Early Warrants and the Notes contain an
issuance limitation prohibiting the Fund from exercising those securities to the
extent that such exercise  would result in  beneficial  ownership by the Fund of
more than 4.99% of the Shares then issued and  outstanding  (the "4.99% Issuance
Limitation").  The December Warrants contain an issuance limitation  prohibiting
the Fund from exercising those securities to the extent that such exercise would
result in beneficial ownership by the Fund of more than 9.99% of the Shares then
issued and outstanding  (the "9.99%  Issuance  Limitation" and together with the
4.99% Issuance Limitation, the "Issuance Limitations"). The Issuance Limitations
may be waived by the Fund upon at least 75 days prior notice to the Company and,
other than in the case of the July Warrant #1, the July Warrant #2, the December
Warrant #1 and the December Warrant #2, shall also automatically become null and
void upon the occurrence  and/or  continuance of an Event of Default (as defined
in and pursuant to the terms of the applicable  instrument).  In the case of the
July Warrant #1, the July  Warrant #2, the December  Warrant #1 and the December
Warrant #2, the Issuance  Limitations shall also become  automatically  null and
void following notice to the Issuer of the occurrence  and/or  continuance of an
Event of Default  (as  defined in and  pursuant  to the terms of the  applicable
instrument).  The Fund is managed by Laurus Capital Management, LLC. Eugene Grin
and David Grin, through other entities, are the controlling principals of Laurus
Capital  Management,  LLC and share sole  voting and  investment  power over the
securities owned by the Fund reported in this Schedule 13G, as amended.


--------------------------------------------------------------------------------
CUSIP No. 09060J106
--------------------------------------------------------------------------------
1     NAME OF REPORTING PERSON:

      Eugene Grin
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                         (a) |_|
                                                                         (b) |_|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
NUMBER OF         5     SOLE VOTING POWER:
SHARES
BENEFICIALLY            0 shares of Common Stock.*
OWNED BY          --------------------------------------------------------------
EACH              6     SHARED VOTING POWER:
REPORTING
PERSON                  1,392,420 shares of Common Stock.*
                  --------------------------------------------------------------
                  7     SOLE DISPOSITIVE POWER:

                        0 shares of Common Stock.*
                  --------------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER:

                        1,392,420 shares of Common Stock.*
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,392,420 shares of Common Stock.
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                             |X|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

      9.99%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON

      IN
--------------------------------------------------------------------------------


------------
      * Based on  13,938,146  shares of the common  stock,  par value $0.001 per
share (the "Shares") of  BioDelivery  Sciences  International,  Inc., a Delaware
corporation  (the  "Company")  outstanding,  as  represented  in  the  Company's
Quarterly  Report on Form 10-QSB for the period ended  September 30, 2006. As of
December 31, 2006, Laurus Master Fund, Ltd. (the "Fund") held (i) a common stock
purchase warrant (the "June Warrant #1") to acquire 22,500 Shares at an exercise
price of $0.001 per Share, subject to certain  adjustments,  (ii) a common stock
purchase  warrant (the "June Warrant #2") to acquire 7,500 Shares at an exercise
price of $0.001 per Share, subject to certain adjustments,  (iii) a common stock
purchase  warrant  (the  "January  Warrant #1") to acquire  39,574  Shares at an
exercise  price of $0.001 per Share,  subject  to  certain  adjustments,  (iv) a
common stock  purchase  warrant  (the  "January  Warrant #2") to acquire  29,700
Shares at an exercise price of $0.001 per Share, subject to certain adjustments;
(v) a common stock purchase warrant (the "February  Warrant") to acquire 350,000
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vi) a common  stock  purchase  warrant (the "May  Warrant") to acquire  483,871
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vii) a common stock purchase  warrant (the "July Warrant #1") to acquire 47,113
Shares at an exercise price of $3.00 per Share,  subject to certain adjustments;
(viii) a common stock purchase  warrant (the "July Warrant #2" and together with
the June  Warrant #1, the June  Warrant #2, the January  Warrant #1, the January
Warrant #2, the February  Warrant,  the May Warrant and the July Warrant #1, the
"Early  Warrants") to acquire 62,887  Shares,  at an exercise price of $3.00 per
Share, subject to certain adjustments, (ix) a common stock purchase Warrant (the
"December  Warrant #1") to acquire 943,305 Shares, at an exercise price of $3.05
per Share, subject to certain  adjustments,  (x) a common stock purchase warrant
(the  "December  Warrant  #2" and  together  with the  December  Warrant #1, the
"December  Warrants") to acquire 556,695  Shares,  at an exercise price of $3.05
per Share, subject to certain  adjustments,  (xi) a Convertible Term Note in the
aggregate principal amount of $2,500,000,  which is convertible into Shares at a
conversion rate of $2.45 per Share,  subject to certain adjustments ("Note #1");
(xii) a Convertible  Term Note in the aggregate  principal amount of $2,500,000,
which is  convertible  into  Shares at a  conversion  rate of $2.45  per  Share,
subject  to certain  adjustments  ("Note  #2",  and  together  with Note #1, the
"Notes");  and (xiii) 19,403 Shares. The Early Warrants and the Notes contain an
issuance limitation prohibiting the Fund from exercising those securities to the
extent that such exercise  would result in  beneficial  ownership by the Fund of
more than 4.99% of the Shares then issued and  outstanding  (the "4.99% Issuance
Limitation").  The December Warrants contain an issuance limitation  prohibiting
the Fund from exercising those securities to the extent that such exercise would
result in beneficial ownership by the Fund of more than 9.99% of the Shares then
issued and outstanding  (the "9.99%  Issuance  Limitation" and together with the
4.99% Issuance Limitation, the "Issuance Limitations"). The Issuance Limitations
may be waived by the Fund upon at least 75 days prior notice to the Company and,
other than in the case of the July Warrant #1, the July Warrant #2, the December
Warrant #1 and the December Warrant #2, shall also automatically become null and
void upon the occurrence  and/or  continuance of an Event of Default (as defined
in and pursuant to the terms of the applicable  instrument).  In the case of the
July Warrant #1, the July  Warrant #2, the December  Warrant #1 and the December
Warrant #2, the Issuance  Limitations shall also become  automatically  null and
void following notice to the Issuer of the occurrence  and/or  continuance of an
Event of Default  (as  defined in and  pursuant  to the terms of the  applicable
instrument).  The Fund is managed by Laurus Capital Management, LLC. Eugene Grin
and David Grin, through other entities, are the controlling principals of Laurus
Capital  Management,  LLC and share sole  voting and  investment  power over the
securities owned by the Fund reported in this Schedule 13G, as amended.


Item 1(a).  Name of Issuer: BIODELIVERY SCIENCES INTERNATIONAL, INC.

Item 1(b).  Address of Issuer's Principal Executive Offices:
            2501 Aerial Center Parkway Suite 205 Morrisville, NC 27560

Item 2(a).  Name of Person Filing: Laurus Master Fund, Ltd.

                  This  Schedule  13G,  as  amended,  is also filed on behalf of
                  Laurus Capital  Management,  LLC, a Delaware limited liability
                  company,   Eugene   Grin  and  David  Grin.   Laurus   Capital
                  Management,  LLC manages Laurus Master Fund,  Ltd. Eugene Grin
                  and David Grin,  through other  entities,  are the controlling
                  principals of Laurus  Capital  Management,  LLC and share sole
                  voting and  investment  power over the shares  owned by Laurus
                  Master  Fund,  Ltd.  Information  related  to each  of  Laurus
                  Capital  Management,  LLC,  Eugene  Grin and David Grin is set
                  forth on Appendix A hereto.


Item 2(b).  Address of Principal Business Office or if none, Residence:
            c/o Laurus Capital Management, LLC,
            825 Third Avenue, 14th Floor,
            New York, NY 10022

Item 2(c).  Citizenship: Cayman Islands

Item 2(d).  Title of Class of Securities: Common Stock

Item 2(e).  CUSIP Number: 09060J106

Item 3.     Not Applicable

Item 4.     Ownership:

            (a)   Amount Beneficially Owned: 1,392,420 shares of Common Stock*

            (b)   Percent of Class: 9.99%*


            (c)   Number of shares as to which such person has:

                  (i)   sole power to vote or to direct the vote: 0 shares of
                        Common Stock*

                  (ii)  shared power to vote or to direct the vote: 1,392,420
                        shares of Common Stock*

                  (iii) sole power to dispose or to direct the disposition of: 0
                        shares of Common Stock*

                  (iv)  shared power to dispose or to direct the disposition of:
                        1,392,420 shares of Common Stock*

Item 5.     Ownership of Five Percent or Less of a Class: Not applicable

Item 6.     Ownership of More than Five Percent on Behalf of Another Person: Not
            applicable

Item 7.     Identification and Classification of Subsidiary Which Acquired the
            Securities: Not applicable

Item 8.     Identification and Classification of Members of the Group: Not
            applicable

Item 9.     Notice of Dissolution of Group: Not applicable

Item 10.    Certification:

            By signing  below I certify  that,  to the best of my knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.


------------
      * Based on  13,938,146  shares of the common  stock,  par value $0.001 per
share (the "Shares") of  BioDelivery  Sciences  International,  Inc., a Delaware
corporation  (the  "Company")  outstanding,  as  represented  in  the  Company's
Quarterly  Report on Form 10-QSB for the period ended  September 30, 2006. As of
December 31, 2006, Laurus Master Fund, Ltd. (the "Fund") held (i) a common stock
purchase warrant (the "June Warrant #1") to acquire 22,500 Shares at an exercise
price of $0.001 per Share, subject to certain  adjustments,  (ii) a common stock
purchase  warrant (the "June Warrant #2") to acquire 7,500 Shares at an exercise
price of $0.001 per Share, subject to certain adjustments,  (iii) a common stock
purchase  warrant  (the  "January  Warrant #1") to acquire  39,574  Shares at an
exercise  price of $0.001 per Share,  subject  to  certain  adjustments,  (iv) a
common stock  purchase  warrant  (the  "January  Warrant #2") to acquire  29,700
Shares at an exercise price of $0.001 per Share, subject to certain adjustments;
(v) a common stock purchase warrant (the "February  Warrant") to acquire 350,000
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vi) a common  stock  purchase  warrant (the "May  Warrant") to acquire  483,871
Shares at an exercise price of $3.88 per Share,  subject to certain adjustments,
(vii) a common stock purchase  warrant (the "July Warrant #1") to acquire 47,113
Shares at an exercise price of $3.00 per Share,  subject to certain adjustments;
(viii) a common stock purchase  warrant (the "July Warrant #2" and together with
the June  Warrant #1, the June  Warrant #2, the January  Warrant #1, the January
Warrant #2, the February  Warrant,  the May Warrant and the July Warrant #1, the
"Early  Warrants") to acquire 62,887  Shares,  at an exercise price of $3.00 per
Share, subject to certain adjustments, (ix) a common stock purchase Warrant (the
"December  Warrant #1") to acquire 943,305 Shares, at an exercise price of $3.05
per Share, subject to certain  adjustments,  (x) a common stock purchase warrant
(the  "December  Warrant  #2" and  together  with the  December  Warrant #1, the
"December  Warrants") to acquire 556,695  Shares,  at an exercise price of $3.05
per Share, subject to certain  adjustments,  (xi) a Convertible Term Note in the
aggregate principal amount of $2,500,000,  which is convertible into Shares at a
conversion rate of $2.45 per Share,  subject to certain adjustments ("Note #1");
(xii) a Convertible  Term Note in the aggregate  principal amount of $2,500,000,
which is  convertible  into  Shares at a  conversion  rate of $2.45  per  Share,
subject  to certain  adjustments  ("Note  #2",  and  together  with Note #1, the
"Notes");  and (xiii) 19,403 Shares. The Early Warrants and the Notes contain an
issuance limitation prohibiting the Fund from exercising those securities to the
extent that such exercise  would result in  beneficial  ownership by the Fund of
more than 4.99% of the Shares then issued and  outstanding  (the "4.99% Issuance
Limitation").  The December Warrants contain an issuance limitation  prohibiting
the Fund from exercising those securities to the extent that such exercise would
result in beneficial ownership by the Fund of more than 9.99% of the Shares then
issued and outstanding  (the "9.99%  Issuance  Limitation" and together with the
4.99% Issuance Limitation, the "Issuance Limitations"). The Issuance Limitations
may be waived by the Fund upon at least 75 days prior notice to the Company and,
other than in the case of the July Warrant #1, the July Warrant #2, the December
Warrant #1 and the December Warrant #2, shall also automatically become null and
void upon the occurrence  and/or  continuance of an Event of Default (as defined
in and pursuant to the terms of the applicable  instrument).  In the case of the
July Warrant #1, the July  Warrant #2, the December  Warrant #1 and the December
Warrant #2, the Issuance  Limitations shall also become  automatically  null and
void following notice to the Issuer of the occurrence  and/or  continuance of an
Event of Default  (as  defined in and  pursuant  to the terms of the  applicable
instrument).  The Fund is managed by Laurus Capital Management, LLC. Eugene Grin
and David Grin, through other entities, are the controlling principals of Laurus
Capital  Management,  LLC and share sole  voting and  investment  power over the
securities owned by the Fund reported in this Schedule 13G, as amended.


                                    SIGNATURE

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

                                               February 14, 2007
                                               ---------------------------------
                                               Date


                                               /s/ Eugene Grin
                                               ---------------------------------
                                               Eugene Grin
                                               Director


                                   APPENDIX A


A.    Name:                  Laurus Capital Management, LLC,
                             a Delaware limited liability company
      Business Address:      825 Third Avenue, 14th Floor
                             New York, New York 10022
      Place of Organization: Delaware


B.    Name:                  Eugene Grin
      Business Address:      825 Third Avenue, 14th Floor
                             New York, New York 10022

      Principal Occupation:  Director of Laurus Master Fund, Ltd.
                             Principal of Laurus Capital Management, LLC
      Citizenship:           United States


C.    Name:                  David Grin
      Business Address:      825 Third Avenue, 14th Floor
                             New York, New York 10022

      Principal Occupation:  Director of Laurus Master Fund, Ltd.
                             Principal of Laurus Capital Management, LLC
      Citizenship:           Israel


Each of Laurus  Capital  Management,  LLC,  Eugene  Grin and David  Grin  hereby
agrees,  by their execution below,  that the Schedule 13G, as amended,  to which
this Appendix A is attached is filed on behalf of each of them, respectively.

Laurus Capital Management, LLC


/s/ Eugene Grin
---------------------------------
Eugene Grin
Principal
February 14, 2007


/s/ David Grin
---------------------------------
David Grin, on his individual behalf
February 14, 2007


/s/ Eugene Grin
---------------------------------
Eugene Grin, on his individual behalf
February 14, 2007