SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 BioCryst Pharmaceuticals, Inc. (Name of Issuer) Common Stock ($0.01 par value) (Title of Class of Securities) 09058V103 (CUSIP Number) DECEMBER 31, 2010 YEAR END (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [X] Rule 13d-1(c) [ ] Rule 13d-1(d) The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP No. 09058V103 _________________________________________________________________ 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Joseph L. Harrosh _________________________________________________________________ 2 CHECK THE APPROPRIATE BOX (a) [ ] IF A MEMBER OF A GROUP (See Instructions) (b) [ ] _________________________________________________________________ 3 SEC USE ONLY _________________________________________________________________ 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States _________________________________________________________________ | | (7) SOLE VOTING POWER | 2,423,382 SHARES |_____________________________ | | (8) SHARED VOTING POWER | -0- NUMBER OF SHARES BENEFICIALLY |_____________________________ OWNED BY EACH REPORTING | PERSON WITH | (9) SOLE DISPOSITIVE POWER | 2,423,382 SHARES |_____________________________ | | (10) SHARED DISPOSITIVE | POWER | -0- ___________________________________|_____________________________ 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 2,423,382 SHARES COMMON STOCK ($0.01 PAR VALUE). _________________________________________________________________ 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) [ ] _________________________________________________________________ 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) : 5.3945% PER FORM 10Q FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30,2010, THERE WERE 44,923,403 SHARES OUTSTANDING OF COMMON STOCK $0.01 PAR VALUE AS OF OCTOBER 27, 2010. _________________________________________________________________ 14 TYPE OF REPORTING PERSON IN _________________________________________________________________ Item 1. (a) Name of Issuer: BIOCRYST PHARMACEUTICALS, INC. (b) Address of Issuer's Principal Executive Offices: 4505 EMPEROR BLVD SUITE 200 DURHAM, NORTH CAROLINA 27703 PHONE - (919) 859-1302 Item 2. (a) Name of Person Filing: Joseph L. Harrosh (b) Address of Principal Business Office: P.O. BOX 6009 FREMONT, CA 94538 (925)523-3323 (c) Citizenship: United States (d) Title of Class of Securities: Common Stock ($0.01 par value) (e) CUSIP Number: 09058v103 Item 3. If this statement is filed pursuant to Sections 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: (a) [ ] Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o). (b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c). (c) [ ] Insurance company as defined in Section 3(a)(19) of the Act (15 U.S.C. 78c). (d) [ ] Investment company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). (e) [ ] An investment adviser in accordance with Section 240.13d-1(b)(1)(ii)(E); (f) [ ] An employee benefit plan or endowment fund in accordance with Section 240.13d-1(b)(1)(ii)(F); (g) [ ] A parent holding company or control person in accordance with Section 240.13d-1(b)(1)(ii)(G); (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813); (i) [ ] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); (j) [ ] Group, in accordance with Section 240.13d-1(b)(1)(ii)(J). Item 4. Ownership Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. (a) Amount beneficially owned: 2,423,382 SHARES (b) Percent of class: 5.3945% (c) Number of Shares as to which the person has: (i) Sole power to vote or to direct to vote: 2,423,382 SHARES (ii) Share power to vote or to direct to vote: 0 Shares (iii) Sole power to dispose or to direct the disposition of: 2,423,382 SHARES (iv) Shared power to dispose or to direct the disposition of: 0 Shares Item 5. Ownership of Five Percent or Less of a Class If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [ ]. Item 6. Ownership of More than Five Percent on Behalf of Another Person If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than five percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of empolyee benefit plan pension fund endowment fund is not required. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. Item 8. Identification and Classification of Memebers of the Group If a group has filed this schedule pursuant to Section 240.13d- 1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each memeber group. If a group has filed this schedule pursuant to Section 240.13d-1(c) or Section 240.13d-1(d), attach an exhibit stating the identity of each member group. Item 9. Notice of Dissolution of Group Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See item 5 Item 10. Certification (a) The following certification shall be included if the statement is filed pursuant to Section 240.13d-1(b): By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securites and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. (b) The following certification shall be included if the statement is filed pursuant to Section 240.13d-1(c): By signing below I certify that to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct. Date: JANUARY 10, 2011 /s/ JOSEPH L. HARROSH