FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person *   HEALTHCARE VENTURES VI LP 2. Date of Event Requiring Statement (Month/Day/Year) 06/27/2006 3. Issuer Name and Ticker or Trading Symbol REPLIDYNE INC [RDYN] (Last) (First) (Middle) HEALTHCARE VENTURES LLC, 44 NASSAU STREET 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) PRINCETON, NJ 08542 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 0 D Â

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Convertible Preferred (1)	  (1)	  (1)	Common Stock	8,250,300 (1)	$ 0	I (3)	and Direct
Series C Convertible Preferred (2)	  (2)	  (2)	Common Stock	7,280,001 (2)	$ 0	I (3)	and Direct

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
HEALTHCARE VENTURES VI LP HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â
HEALTHCARE PARTNERS VI LP HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â
CAVANAUGH JAMES H HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â
LITTLECHILD JOHN W 55 CAMBRIDGE PARKWAY SUITE 301 CAMBRIDGE, MA 02142	Â	  X	Â	Â
WERNER HAROLD R HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â
Mirabelli Christopher 55 CAMBRIDGE PARKWAY SUITE 301 CAMBRIDGE, MA 02142	Â	  X	Â	Â
AGUIAR ERIC HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â
CROUSE WILLIAM W HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON, NJ 08542	Â	  X	Â	Â

Signatures

/s/Jeffrey Steinberg, Administrative Partner, HealthCare Ventures VI, L.P.		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Administrative Partner, HealthCare Partners VI, L.P.		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for James H. Cavanaugh		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for John Littlechild		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for Harold Werner		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for Christopher Mirabelli		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for Eric Aguiar		06/27/2006
**Signature of Reporting Person		Date
/s/Jeffrey Steinberg, Attorney-in-Fact for William Crouse		06/27/2006
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These shares will automatically convert into 1,682,361 shares of Common Stock of the Issuer on the date of the closing of the initial public offering of the Issuer's Common Stock.
(2)	These shares will automatically convert into 1,484,502 shares of Common Stock of the Issuer on the date of the closing of the initial public offering of the Issuer's Common Stock.
(3)	These securities are owned by HealthCare Ventures VI, L.P. ("HCVVI"). These securities are indirectly owned by HealthCare Partners VI, L.P. ("HCPVI"), the General Partner of HCVVI, and each of James Cavanaugh, Harold Werner, John Littlechild, Christopher Mirabelli, William Crouse, Augustine Lawlor and Eric Aguiar, general partners of HCPVI. Drs. Cavanaugh, Mirabelli and Aguiar and Messrs. Werner, Littlechild, Lawlor and Crouse disclaim beneficial ownership of those securities in which they do not have a pecuniary interest and this report shall not be deemed an admission that they are the beneficial owners of these securities for purposes of Section 16, except to the extent of their pecuniary interest therein.

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