Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
CMEA VENTURES VI LP
  2. Issuer Name and Ticker or Trading Symbol
TETRAPHASE PHARMACEUTICALS INC [TTPH]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
1 LETTERMAN DR. BLDG C, SUITE CM500
3. Date of Earliest Transaction (Month/Day/Year)
03/25/2013
(Street)

SAN FRANCISCO, CA 94129
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/25/2013   C   1,693 A (1) 1,693 (2) D  
Common Stock 03/25/2013   C   70,376 A (1) 70,376 (3) D  
Common Stock 03/25/2013   C   2,208 A (1) 3,901 (2) D  
Common Stock 03/25/2013   C   91,795 A (1) 162,171 (3) D  
Common Stock 03/25/2013   C   9,250 A (1) 13,151 (2) D  
Common Stock 03/25/2013   C   384,613 A (1) 546,784 (3) D  
Common Stock 03/25/2013   C   23,639 A (1) 36,790 (2) D  
Common Stock 03/25/2013   C   982,275 A (1) 1,529,059 (3) D  
Common Stock 03/25/2013   P   14,786 A $ 7 51,576 (2) D  
Common Stock 03/25/2013   P   628,071 A $ 7 2,157,130 (3) D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A-1 Convertible Participating Preferred Stock (1) 03/25/2013   C     49,088   (1)   (4) Common Stock 1,693 (1) (2) $ 0 0 D  
Series A-1 Convertible Participating Preferred Stock (1) 03/25/2013   C     2,040,912   (1)   (4) Common Stock 70,376 (1) (3) $ 0 0 D  
Series A-2 Convertible Participating Preferred Stock (1) 03/25/2013   C     64,027   (1)   (4) Common Stock 2,208 (1) (2) $ 0 0 D  
Series A-2 Convertible Participating Preferred Stock (1) 03/25/2013   C     2,662,059   (1)   (4) Common Stock 91,795 (1) (3) $ 0 0 D  
Series B Convertible Participating Preferred Stock (1) 03/25/2013   C     268,269   (1)   (4) Common Stock 9,250 (1) (2) $ 0 0 D  
Series B Convertible Participating Preferred Stock (1) 03/25/2013   C     11,153,776   (1)   (4) Common Stock 384,613 (1) (3) $ 0 0 D  
Series C Convertible Participating Preferred Stock (1) 03/25/2013   C     685,531   (1)   (4) Common Stock 23,639 (1) (2) $ 0 0 D  
Series C Convertible Participating Preferred Stock (1) 03/25/2013   C     28,485,997   (1)   (4) Common Stock 982,275 (1) (3) $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
CMEA VENTURES VI LP
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
CMEA Ventures VI GmbH & Co. KG
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
CMEA Ventures VI Management, L.P.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Handelsman Karl D.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Collier David J
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Watson James F
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
Sohail Faysal A.
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    
BARUCH THOMAS R
1 LETTERMAN DR. BLDG C, SUITE CM500
SAN FRANCISCO, CA 94129
    X    

Signatures

 CMEA Ventures VI, L.P. By: CMEA Ventures VI Management, L.P., its General Partner By: /s/ Karl Handelsman, General Partner   03/27/2013
**Signature of Reporting Person Date

 CMEA Ventures VI, GmbH & CO. KG By: CMEA Ventures VI Management, L.P., its General Partner By: /s/ David Collier, its General Partner   03/27/2013
**Signature of Reporting Person Date

 CMEA Ventures VI Management, L.P. By: /s/ Faysal Sohail, its General Partner   03/27/2013
**Signature of Reporting Person Date

 /s/ Karl Handelsman   03/27/2013
**Signature of Reporting Person Date

 /s/ David Collier   03/27/2013
**Signature of Reporting Person Date

 /s/ James Watson   03/27/2013
**Signature of Reporting Person Date

 /s/ Faysal Sohail   03/27/2013
**Signature of Reporting Person Date

 /s/ Thomas Baruch   03/27/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The Series A-1, Series A-2, Series B and Series C Convertible Preferred Stock converted into Common Stock on a 1-for-29 basis upon the closing of the issuer's initial public offering without payment of consideration.
(2) Held by CMEA Ventures VI, GmbH & Co. KG. The general partner of CMEA Ventures VI, GmbH & Co. KG is CMEA Ventures VI Management, L.P. The general partners of CMEA Ventures VI Management, L.P. are Karl Handelsman, David Collier, Faysal Sohail, Thomas Baruch and James Watson. CMEA Ventures VI Management, L.P. and each of these individuals exercises shared voting and investment power over the shares held of record by CMEA Ventures VI, GmbH & Co. KG. Each of the filing persons disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(3) Held by CMEA Ventures VI, L.P. The general partner of CMEA Ventures VI, L.P. is CMEA Ventures VI Management, L.P. The general partners of CMEA Ventures VI Management, L.P. are Karl Handelsman, David Collier, Faysal Sohail, Thomas Baruch and James Watson. CMEA Ventures VI Management, L.P. and each of these individuals exercises shared voting and investment power over the shares held of record by CMEA Ventures VI, L.P. Each of the filing persons disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(4) Not applicable.

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