Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Dere Willard H
 2. Date of Event Requiring Statement (Month/Day/Year)
12/13/2004		 3. Issuer Name and Ticker or Trading Symbol
AMGEN INC [AMGN]
(Last)
(First)
(Middle)
ONE AMGEN CENTER DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Sr. V.P., Global Dev & CMO
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

THOUSAND OAKS, CA 91320-1799		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 9,550
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
ISO (Right to Buy) 03/15/2005(1) 03/15/2011 Common Stock 3,362 $ 59.48 D  
ISO (Right to Buy) 07/07/2004(2) 07/07/2010 Common Stock 5,804 $ 68.91 D  
NQSO (Right to Buy) 03/15/2005(3) 03/15/2011 Common Stock 11,934 $ 59.48 D  
NQSO (Right to Buy) 07/07/2004(4) 07/07/2010 Common Stock 34,196 $ 68.91 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Dere Willard H
ONE AMGEN CENTER DRIVE
THOUSAND OAKS, CA 91320-1799		       Sr. V.P., Global Dev & CMO  

Signatures

/s/ William H. Dere 12/15/2004
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) (WHD ISO 3/04) This option becomes exercisable in two equal installments of 1,681 shares each commencing 3/15/2008.
(2) (WHD ISO 7/03) This option becomes exercisable in four equal installments of 1,451 shares each commencing 7/7/2004.
(3) (WHD 3/04) This option becomes exercisable in three equal installments of 3,059 shares each and a final installment of 1,378 shares commencing 3/15/2005.
(4) (WHD 7/03) This option becomes exercisable in four equal installments of 8,549 shares each commencing 7/7/2004.

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